Analysis of the Relationship between the Recovery of Thyroid Function and the Growth and Development of Children with Newly Screened High TSH Hyperthyroidemia
YAN Xue-qin, XIE Jie-yan, SHANGGUAN Yu-mei, et al
Child Healthcare Department,Bo'ai Hospital of Zhongshan City, Guangdong Province, 528403
Abstract：【Objective】To explore the relationship between the recovery of thyroid function and the growth and development of children with newly screened TSH (thyroid stimulating hormone) hyperthyroidemia, and to provide references for the formulation of therapeutic indications and treatment goals. 【Methods】 A total of 281 children with newly screened high TSH hyperthyroidemia who were admitted to our hospital from February 2014 to February 2017, according to the recovery of thyroid function during follow-up , were divided into the TSH natural recovery group and the drug treatment group. In the same time period, 60 healthy children of similar age were selected as the control group. We compared the intelligence and growth development of the three groups at the age of one year, and analyzed the effects of serum TSH on children's growth and development.【Results】Of the 281 cases of high TSH hyperthyroidemia patients, 237 cases (84.34%) showed their TSH returned to normal level naturally (without any treatment) during the follow-up period, of which 176 cases returned to normal within 3 months, 55 cases return to normal within 3~6 months, and 6 cases returned to normal within 6~9 months. The remaining 44 patients with high serum TSH more than 15 mIU/mL during the initial or follow-up period received levothyroxine sodium tablets. Of these, 35 cases returned to normal serum TSH level after treatment. However, the remaining 9 patients still maintained at high TSH hyperthyroidemia even after receiving the treatment. There were no significant differences between the MDI (mental development index) and PDI (psychological development index) scores of the three groups of children at the age of one year (P>0.05). The children's height of the three groups at the age of one year did not show significant difference (P>0.05).【Conclusion】The thyroid function of most children with newly screened high serum TSH hyperthyroidemia can return to normal in a short time, and high TSH hyperemia does not have a significant influence on the growth and development of children.Clinical treatment indications should be carefully judged to avoid overtreatment.
严学勤, 谢洁妍, 上官予梅, 林翠兰, 陈小兰. 新筛高TSH血症患儿甲状腺功能恢复情况与生长发育状况的关系分析[J]. 医学临床研究, 2018, 35(6): 1047-1049.
YAN Xue-qin, XIE Jie-yan, SHANGGUAN Yu-mei, et al. Analysis of the Relationship between the Recovery of Thyroid Function and the Growth and Development of Children with Newly Screened High TSH Hyperthyroidemia. JOURNAL OF CLINICAL RESEARCH, 2018, 35(6): 1047-1049.
[1] Child CJ, Blum WF, Deal C,et al. Development of additional pituitary hormone deficiencies in pediatric patients originally diagnosed with isolated growth hormone deficiency due to organic causes[J].Eur J Endocrinol,2016, 174(5): 669-679. [2] 张文娟, 张春丽, 陈俊龙. 新生儿高促甲状腺激素血症临床转归分析[J].航空航天医学杂志, 2017, 28(1): 72-73. [3] Singh S, Yazdani U, Gadad B, et al. Serum thyroid-stimulating hormone and interleukin-8 levels in boys with autism spectrum disorder[J].J Neuroinflammation,2017, 14(1): 113. [4] Moran C, Habeb A M, Kahaly G J, et al. Homozygous Resistance to Thyroid Hormone β: Can Combined Antithyroid Drug and Triiodothyroacetic Acid Treatment Prevent Cardiac Failure [J].J Endocr Soc,2017, 1(9): 1203-1212. [5] 潘玲琳, 钱红艳, 匡晓妮, 等. 新生儿高TSH血症的转归及体格智能发育研究[J].微量元素与健康研究, 2016, 33(5): 25-27. [6] Su PH, Chen HY, Chen SJ, et al. Thyroid and growth hormone concentrations in 8-year-old children exposed in utero to dioxins and polychlorinated biphenyls[J].J Toxicol Sci,2015, 40(3): 309-319. [7] Trumpff C, De Schepper J, Vanderfaeillie J, et al. Neonatal thyroid-stimulating hormone concentration and psychomotor development at preschool age[J].Arch Dis Child,2016, 101(12): 1100-1106. [8] 许晓红. 妊娠与哺乳期抗甲状腺治疗对子代生长发育的影响[J].临床医药文献电子杂志, 2016, 3(50): 9908-9908. [9] Kumari T, Prasad A, Sinha KK, et al. Age and sex specific thyroid hormone profile in euthyroid subjects[J].J Biochem Technol,2016, 6(3): 1008-1012. [10] 潘玲琳, 钱红艳, 匡晓妮, 等. 新生儿部分高促甲状腺素血症的自然转归及治疗时机的临床研究[J].中国儿童保健杂志, 2016, 24(2): 131-133. [11] Lain SJ, Bentley JP, Wiley V, et al. Association between borderline neonatal thyroid-stimulating hormone concentrations and educational and developmental outcomes: a population-based record-linkage study[J].Lancet Diabetes Endocrinol,2016, 4(9): 756-765. [12] Wilken JA, Greenspan LC, Kushi LH, et al. Thyroid Hormones and Timing of Pubertal Onset in a Longitudinal Cohort of Females, Northern California, 2006-2011[J].Paediatr Perinat Epidemiol,2016, 30(3): 285-293. [13] 潘莉珍, 谢莉, 郑敏, 等. 新生儿高促甲状腺激素血症患儿随访分析[J].中国妇幼保健, 2016, 31(5): 965-968. [14] Sergeyev O, Burns JS,Williams PL, et al. The association of peripubertal serum concentrations of organochlorine chemicals and blood lead with growth and pubertal development in a longitudinal cohort of boys: a review of published results from the Russian children's study[J].Rev Environ Health,2017, 32(1-2): 83-92. [15] 董丽萍, 朱峰, 李萍. 181636例新生儿先天性甲状腺功能减低症筛查与随访分析[J].中国现代医生, 2016, 54(4): 125-127. [16] 吕亚囡, 李文杰, 吕金峰. 新生儿先天性甲状腺功能低下症的筛查与治疗[J].中国妇幼保健, 2017, 32(10): 2118-2121. [17] Asakura Y, Abe K, Muroya K, et al. Combined growth hormone and thyroid-stimulating hormone deficiency in a Japanese patient with a novel frameshift mutation in IGSF1[J].Horm Res Paediatr,2015, 84(5): 349-354. [18] Krause M, Frederiksen H, Sundberg K, et al. Maternal exposure to UV filters: associations with maternal thyroid hormones, IGF-I/IGFBP3 and birth outcomes[J].Endocr Connect,2018, 7(2): 334-346.
2018, Vol. 35 
