Abstract：【Objective】To investigate the correlation of levels of interleukin-10 (IL-10),interleukin-17 (IL-17),and intercellular adhesion molecule-1(ICAM-1) with the severity of children bronchial asthma.【Methods】A total of 120 children with bronchial asthma admitted to our hospital from December 2019 to December 2022 were selected as the observation group. According to the severity of bronchial asthma status,patients were further divided into the mild group,the moderate group,and the severe group. In the same time period,60 healthy children who underwent physical examination in our hospital were selected as the control group. The receiver operating characteristic (ROC) curve was used to analyze the value of analyzing the levels of IL-10,IL-17,and ICAM-1 using in predicting the occurrence of bronchial asthma. Spearman rank correlation analysis was applied to analyze the correlation between levels of IL-10,IL-17,ICAM-1 and the severity of the disease.【Results】The level of IL-10 in the observation group was lower than that in the control group (P<0.05),while the levels of IL-17 and ICAM-1 were higher than those in the control group (P<0.05). ROC curve analysis showed that the areas under the curve of IL-10,IL-17,and ICAM-1 in predicting the occurrence of bronchial asthma were 0.868,0.839,and 0.987,respectively (all P<0.05). The trend of IL-10 level was mild group>moderate group>severe group (P<0.05),while the trends of both IL-17 level and ICAM-1 level were in the order of mild group<moderate group<severe group (P<0.05). The level of IL-10 is negatively correlated with the severity of the disease condition (rs=-0.561,P<0.05),while the levels of IL-17 and ICAM-1 were positively correlated with the severity of the disease condition (rs=0.539,0.584,all P<0.05).【Conclusion】IL-10,IL-17,and ICAM-1 have a high predictive value for the occurrence of bronchial asthma in children,and the levels of IL-10,IL-17,and ICAM-1 in children with bronchial asthma are significantly correlated with the severity of the disease. The above indicators can be monitored clinically to predict the occurrence and progression of the disease.
陈春梅. IL-10、IL-17及ICAM-1水平与支气管哮喘患儿病情严重程度的相关性分析[J]. 医学临床研究, 2023, 40(9): 1328-1330.
CHEN Chunmei. Correlation Analysis of Levels of IL-10,IL-17,and ICAM-1 with the Severity of Bronchial Asthma in Children. JOURNAL OF CLINICAL RESEARCH, 2023, 40(9): 1328-1330.
[1] 胡倩,吴松泽,刘春涛.成都地区14岁以上人群哮喘患病率及相关危险因素的流行病学调查[J].中国呼吸与危重监护杂志,2020,19(2):183-189. [2] ZHANG Y,ZHAO C F,ZHAO X X,et al. Interleukin-25 in sputum as a marker of airway inflammation in children asthma[J].Sci China Life Sci,2019,62(12):1605-1608. [3] YI L X,WENG T J,NIE P H,et al. Overexpression of interleukin-10 in engineered macrophages protects endothelial cells against LPS-induced injury in vitro[J].FEBS Open Bio,2022,12(3):605-615. [4] KUMAR R,THEISS A,VENUPRASAD K. RORγt protein modifications and IL-17-mediated inflammation[J].Trends immunol,2021,42(11):1037-1050. [5] CHEN Q Z,ZHOU Y B,ZHOU L F,et al. TRPC6 modulates adhesion of neutrophils to airway epithelial cells via NF-κB activation and ICAM-1 expression with ozone exposure[J].Exp Cell Res,2019,377(1):56-66. [6] 中华医学会儿科学会呼吸学组,《中华儿科杂志》编辑委员会.儿童支气管哮喘诊断与防治指南[J].中华儿科杂志,2008,46(10):745-753. [7] 戴伟,吴海兰,赵明,等.外泌体在支气管哮喘发病机制中的作用[J].中华结核和呼吸杂志,2020,43(1):67-70. [8] 姜慧妍,严思敏,吴秋惠,等.呼出气一氧化氮指导支气管哮喘患者使用吸入性糖皮质激素治疗效果的研究[J].中国医院药学杂志,2021,41(7):696-699. [9] 程云,杨武,孙磊.特布他林联合布地奈德治疗儿童哮喘对炎性细胞因子的影响及其遗传因素分析[J].儿科药学杂志,2021,27(7):25-28. [10] 胡小容,张承,徐刚.降钙素原、IFN-γ和IL-10联合检测在支气管哮喘患者中变化及意义的相关性分析[J].标记免疫分析与临床,2018,25(2):250-252. [11] 徐凌云,夏敏,李亚琴,等.支气管哮喘患儿血清中的IL-10、IL-12、IFN-γ、Eotaxin水平检测及其临床意义[J].贵州医药,2019,43(11):1711-1713. [12] 马玉,戴银芳,张新星,等.支气管哮喘患儿呼出气一氧化氮水平与外周血中IL-9、IL-17的相关性研究[J].中国实用儿科杂志,2020,35(3):222-227. [13] 周洁,吉玲,王新华,等.细胞间黏附分子-1在支气管哮喘儿童支气管黏膜中的表达及其对支气管上皮细胞凋亡的影响[J].新乡医学院学报,2019,36(2):126-130. [14] 张长生,张海涛.支气管哮喘患者细胞间黏附因子-1、嗜酸粒细胞的水平变化及临床意义[J].中国医药导报,2020,17(1):94.
2023, Vol. 40 
