Abstract：【Objective】To explore the value of cognitive behavioral therapy (CBT) combined with medication treatment on non-suicidal self-injury (NSSI) in adolescents with depression.【Methods】Eighty non-NSSI adolescents with depression from our hospital were randomly divided into an observation group and a control group,with 40 cases in each group. The patients in the control group received medication treatment,while patients in the observation group received CBT combined with medication treatment. The therapeutic effects,occurrence of adverse reactions,Hamilton Depression Rating Scale (HAMD) scores,Self-Rating Depression Scale (SDS) scores,Self-Rating Anxiety Scale (SAS) scores,Coping Style Questionnaire (CSQ) scores,as well as levels of brain-derived neurotrophic factor (BDNF),neuropeptide Y (NPY),and serotonin (5-HT) were compared between the two groups before and after treatment.【Results】The total effective rate in the observation group was 87.50% (35/40),which was significantly higher than the control group's 67.50% (27/40),and the difference was statistically significant (P<0.05). The HAMD scores,SDS scores,and SAS scores in both groups after treatment were significantly lower than those before treatment,while these scores in the observation group were lower than those in the control group (P<0.05). There were no statistically significant differences in each factor score of the CSQ evaluation in the control group before and after treatment (P>0.05). After treatment,the scores of problem-solving and help-seeking factors in the observation group were significantly higher than those before treatment and the control group (P<0.05),the scores of avoidance and self-blame factors were significantly lower than those before treatment and the control group (P<0.05),There were no statistically significant differences in the scores of fantasy and rationalization factors in the observation group after treatment if compared to before treatment and the control group (P>0.05). The levels of BDNF,NPY,and 5-HT in both groups were significantly higher after treatment compared to before treatment (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】CBT combined with medication treatment has good effects on improving depressive symptoms,coping skills,and autonomic nervous function in NSSI adolescents with depression. It is relatively safe as well.
马雪红, 杨宗儒, 何艳琴. 认知行为疗法联合药物治疗青少年抑郁症非自杀性自伤患者的效果[J]. 医学临床研究, 2023, 40(9): 1324-1327.
MA Xuehong, YANG Zongru, HE Yanqin. Effect of Cognitive Behavioral Therapy Combined with Medication Treatment on Non-Suicidal Self-Injury in Adolescents with Depression. JOURNAL OF CLINICAL RESEARCH, 2023, 40(9): 1324-1327.
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2023, Vol. 40 
