摘要目的探讨青少年肥胖家族史与高三酰甘油血症‐腰围表型（HTWC）的关系。方法采用分层整群随机抽样方法，对秦皇岛地区3136名13～17岁汉族青少年进行横断面调查。根据父母有无肥胖分为无肥胖家族史组（ n＝1967）和有肥胖家族史组（ n＝1169）。检测调查对象的三酰甘油（T G ）水平及测量身高、体质量及腰围（WC），并计算体质量指数（BMI）。以WC≥同年龄同性别青少年WC的90百分位值且 TG≥1．47 mmol／L定义为HTWC表型。结果有肥胖家族史青少年平均WC和TG均显著高于无肥胖家族史青少年（ P ＜0．05）。有肥胖家族史青少年 HTWC表型高于无肥胖家族史青少年（4．4％ vs 2．5％，χ2＝8．468， P ＝0．004）。以 HTWC表型为因变量，以年龄、性别和肥胖家族史为自变量，行多因素logistic回归显示，肥胖家族史（OR＝1．735，95％ CI：1．167～2．578，P＝0．006）为HTWC表型的独立危险因素。结论肥胖家族史与青少年 HTWC表型密切相关，为青少年 HTWC表型的独立危险因素。
Abstract：[Objective]To explore the relationship between a family history of obesity and hypertriglyceridemic‐waist (HTWC) phenotype in adolescents .[Methods]A cross‐sectional study was conducted for 3 ,136 Han adoles‐cents aged 13~17 years in Qinhuangdao through stratified and cluster sampling .The HTWC phenotype was defined as serum triglyceride concentrations ≥1 .47 mmol/L and waist circumference ≥90th percentile for age and gender . Based on a family history of obesity ,they were divided into two groups of positive family history ( n =1169) and negative family history ( n =1967) .The triglyceride concentrations ,height ,weight and waist circumference were measured .And body mass index was calculated .[Results]Waist circumference and serum triglyceride were significant‐ly higher in adolescents with a family history of obesity than those in adolescents without a family history of obesity ( P<0 .05) .The prevalence of HTWC phenotype was significantly higher in adolescents with family history than that in those without family history (4 .4% vs 2 .5% ,χ2 =8 .468 ,P =0 .004) .After adjusting for gender and age ,the prevalence of HTWC phenotype among adolescents with family history was 1 .735 (95% CI:1 .167~2 .578 ,P =0 .006) folds of those without family history .[Conclusion]A significant correlation exists between a family history of obesity and HTWC phenotype .And it suggests that a family history of obesity is an independent risk factor for HT‐WC phenotype .
2015, Vol. 32 
