Abstract：【Objective】To investigate the correlation between serum Nesfatin-1 level and mild cognitive impairment in patients with Type 2 diabetes mellitus complicated with hypertension. 【Methods】A total of 786 elderly patients with T2DM treated in our hospital from December 2018 to January 2020 were divided into simple T2DM group (group A), T2DM + hypertension subgroup (subgroup B1) and T2DM + hypertension + MCI subgroup (subgroup B2). The levels of fasting blood glucose (FPG), fasting insulin, homocysteine (Hcy), total cholesterol (TC), low density lipoprotein (LDL-C), triglyceride (TG), high density lipoprotein (HDL-C), high sensitivity C-reactive protein (hs-CRP), neuronal enolase (NSE), glycosylated hemoglobin (HbA1c) and Nesfatin-1 were compared, and the insulin sensitivity index (ISI) was calculated. Logistic multivariate regression analysis was used to analyze the related risk factors of MCI in elderly T2DM patients with hypertension. 【Results】 The levels of FPG, Nesfatin-1, LDL-C, ISI and Hcy in the B1 subgroup and the B2 subgroup were significantly higher than those in the group A (P<0.05); The levels of BMI, FPG, Nesfatin-1, ISI, LDL-C and NSE in the subgroup B2 were significantly higher than those in the subgroup B1 (P<0.05), and the level of NSE was significantly higher than that in the group A (P<0.05). Pearson correlation analysis showed that serum Nesfatin-1 was positively correlated with BMI, FPG, HbA1c, NSE and Hcy (P<0.05), and negatively correlated with ISI (P<0.05). Logistic multivariate regression analysis showed that FPG, BMI and Nesfatin-1 were the risk factors of MCI in T2DM patients with hypertension. 【Conclusion】 Serum Nesfatin-1 level, FPG and BMI are the risk factors of MCI in T2DM patients with hypertension. It is of great significance to effectively control body weight, improve fasting blood glucose level and increase insulin sensitivity.
刘小阳, 郑桃林, 刘超, 龙艳, 余承裕, 万华平, 邢红专, 范方松, 秦惠惠. 血清Nesfatin-1水平与2型糖尿病合并高血压患者发生轻度认知功能障碍的相关性[J]. 医学临床研究, 2022, 39(3): 349-351.
LIU Xiao-yang, ZHENG Tao-lin, LIU Chao, et al. Relationship between Serum Nesfatin-1 Level and Mild Cognitive Impairment in Patients with Type 2 Diabetes Mellitus Complicated with Hypertension. JOURNAL OF CLINICAL RESEARCH, 2022, 39(3): 349-351.
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2022, Vol. 39 
