Abstract：【Objective】To investigate the effect of nanostructured coating combined with antiseptic sealant on periodontal pathogens and bone density of implants. 【Methods】A total of 190 patients with mandibular implants in our hospital from January 2018 to January 2020 were enrolled, and divided into five groups according to admission orders, each with 38 cases. Control group treated without sealant, routine group treated with implant sealant,nano group treated with nanostructured coating, antiseptic group treated with antiseptic sealant, and combined group received nanostructured coating combined with antiseptic sealant. Patients were followed up from treatment till post-treatment 12 months. Then the implant stability, implant success rate, periodontal pathogens and bone density were compared among groups. 【Results】At the moment of bonding and 3 months,6 months,and 12 months after loading,the implant stability quotient (ISQ) values from low to high were the control group,the conventional group,the antibacterial group,the nano group,and the combined group,with statistical differences(P<0.05),and the isq values at the moment of bonding in each group were higher than those after loading(P<0.05).With the extension of loading time,the number of Staphylococcus aureus,oral inherent Streptococcus sanguis and Porphyromonas gingivalis in the control group,routine group,nano group,antibacterial group and combined group increased.There was a statistical difference between the number of Staphylococcus aureus,oral inherent Streptococcus sanguis and Porphyromonas gingivalis 3 months,6 months and 12 months after loading and immediately after bonding(P<0.05).The increase of pathogenic bacteria in the combined group was the lowest and lower than that in the other four groups(P<0.05).At 6 and 12 months after loading,the bone mineral density of the combined group was higher than that of the nano group and the antibacterial group,and the bone mineral density of the nano group was higher than that of the antibacterial group,the difference was statistically significant(P<0.05). 【Conclusion】Application of nanostructured coating combined with antiseptic sealant can effectively ameliorate the periodontal pathogens and bone density, and improve the implant stability.
解碧晶, 张钰涓, 尤亦欣. 纳米结构涂层密封剂联合抗菌密封剂对种植体牙周病原菌及骨密度的影响[J]. 医学临床研究, 2022, 39(12): 1844-1847.
XIE Bi-jing, ZHANG Yu-juan, YOU Yi-xin. Effects of Nanostructure Coating Sealant Combined with Antibacterial Sealant on Periodontal Pathogens and Bone Mineral Density of Implants. JOURNAL OF CLINICAL RESEARCH, 2022, 39(12): 1844-1847.
2022, Vol. 39 
