Abstract：【Objective】To evaluate the bone mineral density (BMD) and bone strength of femoral bone in patients with type 1 diabetes mellitus by quantitative CT, and the relationship with insulin-like growth factor -1 (IGF-1).【Methods】Twenty-five patients with type 1 diabetes mellitus in our hospital were selected as observation group, and 25 healthy subjects in the same period of time in our hospital were selected as control group.Through the three-dimensional quantitative CT, volumetric bone mineral density (vBMD) and bone strength , serum IGF-1, bone alkaline phosphatase (B-ALP), osteocalcin (sOC) and procollagen amino terminal peptide (P I NP) at different parts of femoral bone were calculated ,and the correlation between bone mineral density and bone strength of femoral bone and IGF-1 of type I diabetes mellitus patients were analyzed .【Results】Compared with the control group, the femoral neck cortex vBMD of the observation group was significantly reduced [(582.5 ± 27.7) mg/cm3 vs (558.1± 31.9) mg/cm3,P<0.05];The total vBMD, cortical thickness and cortical cross-sectional area were significantly lower [(258.4 ± 42.9) mg/cm3 vs(223.7± 27.3)mg/cm3;(3.3 ± 0.7)mm vs(2.8 ± 0.5)mm;(5.3 ± 1.2)cm2 vs (4.3 ± 0.5)cm2;mean P<0.01]. Compared with the control group, the BR of the observation group was significantly increased[(10.8 ±1.8) vs(12.9±1.9),P<0.01]; The serum levels of B-ALP, sOC, P I and NP in the observation group and the control group had no significant difference (P>0.05).There was a significant positive correlation between serum IGF-1 and total vBMD of femoral neck in patients with type 1 diabetes mellitus (r=0.48; P<0.05).【Conclusion】Quantitative CT revealed that vBMD, cortical cross-sectional area and cortical thickness were lower in patients with type 1 diabetes. Serum IGF-1 level can significantly affect the total vBMD of femoral neck in patients with type 1 diabetes mellitus.
贺迎花;刘海波;蔡丰伟;张武军;孟昊天. 定量CT评估1型糖尿病患者股骨骨密度和骨强度[J]. 医学临床研究, 2017, 34(2): 272-275.
HE Ying-hua; LIU Hai-bo; CAI Feng-wei; et al. Evaluation of Bone Mineral Density (BMD) and Bone Strength of Femoral Bone in Patients with Type 1 Diabetes Mellitus under Quantitative CT. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 272-275.
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