Analysis of Relationship of Preoperative Lower Respiratory Tract Colonization with Postoperative Pulmonary Infection in Patients with Non-small Cell Lung Cancer
WANG Li, REN Ming-zhi, JIANG Peng
Department of Oncology,Xi'an International Medical Center Hospital,Shaanxi Xi'an 710100
Abstract：【Objective】To investigate the relationship of preoperative lower respiratory tract colonization with postoperative pulmonary infection in patients with non-small cell lung cancer (NSCLC). 【Methods】A total of 82 patients with NSCLC who underwent surgery in our hospital from November 2019 to April 2021 were selected as the research subjects. Accorded to the presence or absence of airway colonized pathogen/bacteria in the lower respiratory tract before surgery, they were divided into groups with airway colonization group and non-airway colonization group.The postoperative pulmonary complications of the two groups were compared. The distribution of pathogenic bacteria in patients with lung infection after operation was analyzed. The clinical data of patients with lung infection and uninfected lungs after surgery were compared. Logistic multivariate regression analysis of influencing risk factors of postoperative lung infection in NSCLC patients was analyzed. 【Results】There was no statistically significant difference in the incidence of subcutaneous emphysema, pulmonary embolism, hoarseness, and chylothorax between the airway colonized bacteria group and the non-airway colonized bacteria group (P>0.05). The incidence of pulmonary infection in the airway colonized bacteria group was 25.00%, which was higher than that in the non-airway bacteria group 5.26% (P<0.05). Among 13 patients with lung infections, 23 strains were detected. Of which, gram-negative bacteria, gram-positive bacteria and fungi accounted for 56.52%, 39.13%, and 4.35% of the total number of pathogens, respectively. The proportion of postoperative lung infection patients with smoking history, white blood cell count (WBC), operation time, hospital stay, invasive procedures, and preoperative airway colonized bacteria were higher than those of patients without lung infection (P<0.05). Logistic regression analysis showed that invasive operations and preoperative airway colonization bacteria were risk factors for postoperative lung infection in NSCLC patients (OR=2.852, 3.425, P<0.05). 【Conclusion】Preoperative airway colonized pathogen/bacteria in the lower respiratory tract of NSCLC patients increases the incidence of postoperative lung infection. Invasive procedures and preoperative airway with colonized bacteria are risk factors for postoperative lung infection in NSCLC patients. Attention should be paid to strengthen precautions in clinical practice.
2022, Vol. 39 
