Abstract：【Objective】To analyze the relationship between Prospero related homeobox protein 1 (PROX1) and recurrence after minimally invasive resection of early non-small cell lung cancer(NSCLC).【Methods】A total of 106 patients with early NSCLC who underwent minimally invasive resection were recruited in the study. The expression of PROX1 in cancer tissues and adjacent tissues was detected and compared. The factors of postoperative recurrence were analyzed. In addition, all patients were followed up for 1 year, the recurrence rate was counted, and the survival of patients within 1 year was analyzed by Kaplan Meier method.【Results】The positive expression rate of PROX1 in cancer tissues was higher than that in adjacent tissues (P<0.05). The postoperative recurrence rate was19.81%(21/106). The recurrence group had higher proportion of TNM stage Ⅱ, maximum tumor diameter >3 cm, lymph node metastasis, low or undifferentiation and PROX1 positive expression than those in the non-recurrence group (P<0.05). Multivariate logistic regression analysis showed that TNM stage Ⅱ, maximum tumor diameter >3 cm, lymph node metastasis, low/undifferentiation and PROX1 positive expression were the postoperative recurrenceinfluencing factors of patients with early NSCLC(P<0.05). By the end of one-year follow-up, 1 out of 80 PROX1 positive patients was lost to follow-up,and 12 died.The cumulative survival rate was 84.81%(67/79).Of the 16 PROX1 negative patients,one was lost to follow-up and one died. The cumulative survival rate was 93.33%(14/15).There was no significant difference in the total survival rate curve between the two groups (P>0.05).【Conclusion】The positive expression rate of PROX1 in early NSCLCis high. TNM stage Ⅱ, maximum tumor diameter >3 cm, lymph node metastasis, low or undifferentiated tumorand PROX1 positive expression are all risk factors for recurrence within 1 year. PROX1 is closely related to recurrence after minimally invasive resection of early NSCLC.
侯苏娟, 柯振宇, 路春晖, 张海涛. PROX1与早期非小细胞肺癌微创切除术后复发的关系[J]. 医学临床研究, 2022, 39(4): 521-523.
HOU Su-juan, KE Zhen-yu, LU Chun-hui, et al. Relationship between PROX1 and Recurrence after Minimally Invasive Resection of Early Non-small Cell Lung Cancer. JOURNAL OF CLINICAL RESEARCH, 2022, 39(4): 521-523.
[1] 周俊,吴峰,王亚丽,等. 恶性肿瘤家族史与非小细胞肺癌临床病理特征的关系[J].肿瘤研究与临床,2019,31(5):324-326.
[2] 徐晓琳,田春艳,耿云峰,等. 核因子κB信号通路在宫颈癌、乳腺癌发生发展及治疗中作用的机制研究进展[J].山东医药,2019,59(18):99-103.
[3] 朱隽,余华良,高山,等. 微小RNA-9调节同源异形盒1基因对胃癌细胞生物学功能的影响[J].中国医药,2020,15(1):83-86.
[4] 王书航,王洁.2018年V3版NCCN非小细胞肺癌指南更新要点解读[J].华西医学,2018,33(4):388-392.
[5] 吴炳群,魏慎海,田进涛,等. 不同转移部位的非小细胞肺癌患者的生存时间比较[J].中国肺癌杂志,2019,22(2):105-110.
[6] 赵东丽,梁宪斌,王艳,等. Prospero相关同源异形盒蛋白1在乳腺癌组织中的表达及与预后相关性分析[J].中国癌症杂志,2019,29(4):5.
[7] SEO M,LEE S K,JOO C K. Inhibition of lymphangiogenesis and hemangiogenesis in corneal inflammation by subconjunctival Prox1 siRNA injection in rats [J].Invest Ophthalmol Vis Sci,2020,38(3):271-280.
[8] FRANCOIS M,WIHHELM D,KOOPMAN P. Three-dimensional imaging of Prox1-EGFP transgenic mouse gonads reveals divergent modes of lymphangiogenesis in the testis and ovary [J].PLoS One,2019,12(1):45-54.
[9] WEN W,LI X,YIN M,et al. Selective autophagy receptor SQSTM1/ p62 inhibits Seneca Valley virus replication by targeting viral VP1 and VP3[J].Autophagy,2021,1(15):1-13.
[10] 杨红春,马海,王宇,等. Prox1基因在原发性肝细胞癌中的表达及其与病理学分级及临床分期的相关性研究[J].中国普外基础与临床杂志,2019,18(7):737-740.
[11] 郭雁翔,郭欢,张斌明. 乳腺癌组织中PROX1的表达和临床病理参数之间的相关性及其共表达基因分析[J].中国妇幼保健,2019,34(8):1879-1884.
2022, Vol. 39 
