Effects of Disodium Cantharidinate and Vitamin B6 Injection on Tumor Markers and Adverse Reactions during SOX Regimen in the Treatment of Breast Cancer
GAO Qing-dong, KANG Feng
General Surgery Ward 1,Yulin Second Hospital,Yulin Shaanxi 719000
Abstract：【Objective】 To investigate the effect of disodium cantharidinate and Vitamin B6 injection on tumor markers and adverse reactions in patients with breast cancer treated with SOX chemotherapy. 【Methods】A total of 82 patients with advanced breast cancer were randomly divided into control group and observation group,with 41 cases in each group. The control group was treated with simple SOX chemotherapy,and the observation group was treated with disodium cantharidinate and Vitamin B6 injection on the basis of the control group.Objective response rate (RR),immune function(CD3+,CD4+,CD8+,CD4+/CD8+) and serum tumor markers[carbohydrate antigen 153 (CA-153),carcinoembryonic antigen (CEA),carbohydrate antigen 125 (CA-125)] and changes in the levels of interleukin-17 (IL-17),macrophage migration inhibitory factor (MIF) and tumor necrosis factor-α(TNF-α) were compared between the two groups before and after treatment. The adverse reactions of the two groups were observed. 【Results】The RR of the observation group was 95.12% (39/41),which was significantly higher than that of the control group [80.49% (33/41)](P<0.05). After treatment,the levels of CD3+,CD4+,CD4+/CD8+ in the two groups were higher than those before treatment (P<0.05),and the levels of CD8+ were lower than those before treatment (P<0.05); After treatment,CD3+,CD4+,CD4+/CD8+ in the observation group were higher than those in the control group (P<0.05),and CD8+ was lower than those in the control group (P<0.05). The levels of IL-17,MIF,CA-153,CEA,CA-125 and TNF-α in both groups after treatment were lower than those before treatment (P<0.05); The levels of the above indexes in the observation group were lower than those in the control group after treatment (P<0.05). The total incidence of adverse reactions in the observation group was 29.27% (12/41),and there was no significant difference compared with 31.71% (13/41) in the control group (P>0.05). 【Conclusion】Injection of disodium cantharidinate and vitamin B6 during SOX chemotherapy can improve the curative effect,serum tumor markers and immune function of patients with breast cancer,and the risk of adverse reactions is low,which is worthy of clinical promotion.
高庆东, 康锋. SOX化疗方案治疗乳腺癌期间注射斑蝥酸钠维生素B6对肿瘤标志物及不良反应的影响[J]. 医学临床研究, 2022, 39(7): 969-972.
GAO Qing-dong, KANG Feng. Effects of Disodium Cantharidinate and Vitamin B6 Injection on Tumor Markers and Adverse Reactions during SOX Regimen in the Treatment of Breast Cancer. JOURNAL OF CLINICAL RESEARCH, 2022, 39(7): 969-972.
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2022, Vol. 39 
