Abstract：【Objective】To explore the clinical effect of Huatuo Zaizao pill combined with dual antiplatelet therapy on severe cerebral infarction. 【Methods】A total of 70 patients with severe cerebral infarction were randomly divided into the control group and the observation group, with 35 cases in each group. The control group was treated with dual antiplatelet therapy, while the observation group was treated with Huatuo Zaizao pill combined with dual antiplatelet therapy. After 4 weeks of continuous treatment, the short-term efficacy and the serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α), Nitric oxide (NO), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were compared before and after treatment between the two groups.【Results】The total effective rate of the observation group was 85.71% (30/35), which was significantly higher than that of the control group [62.86%(22/35)](P<0.05). After treatment, levels of IL-6, IL-8 and TNF-α in both groups were significantly lower than those before treatment (P<0.05), and their levels in the observation group was significantly lower than in the control group (P<0.05). While the NO level in the two groups after treatment was significantly higher than that before treatment (P<0.05), and its level in the observation group was significantly higher than that in the control group (P<0.05). Levels of VEGF and ET-1 in the two groups were significantly lower than were significantly lower than those before treatment (P<0.05); and both levels in the observation group were lower than those in the control group (P<0.05). After treatment, SOD and GSH-Px in the two groups were significantly higher than those before treatment (P<0.05), however, levels of SOD and GAH-Px in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the MDA of the two groups was significantly lower than that before treatment (P<0.05), and its level of the observation group was significantly lower than that of the control group (P<0.05). 【Conclusion】Huatuo Zaizao pill combined with dual antiplatelet therapy has nice effects on severe cerebral infarction. It can alleviate inflammatory reaction, improve vascular endothelial function and reduce oxidative stress injury.
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2022, Vol. 39 
