医学临床研究
  2025年4月5日 星期六           首 页    |    期刊简介    |    编委会    |    投稿指南    |    期刊订阅    |    广告合作    |    留言板    |    联系我们    |    English
医学临床研究  2022, Vol. 39 Issue (10): 1463-1465    DOI: 10.3969/j.issn.1671-7171.2022.10.007
  论著 本期目录 | 过刊浏览 | 高级检索 |
肾病综合征患儿他克莫司血药谷浓度监测结果分析
陈军校1, 李娜2*
1.延安大学咸阳医院,陕西 咸阳 712000;
2.咸阳市妇幼保健院,陕西 咸阳 712000
Analysis of Monitoring Results of Tacrolimus Blood Trough Concentration in Children with Nephrotic Syndrome
CHEN Jun-xiao, LI Na
Xianyang Hospital of Yan'an University,Xianyang Shaanxi 712000
全文: PDF (1099 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 【目的】分析肾病综合征(NS)患儿他克莫司血药谷浓度监测结果及其临床指导意义。【方法】选取97例NS患儿作为研究对象,患儿均接受他克莫司治疗,并记录其用药情况。分析患儿性别、年龄、给药剂量与不同血药谷浓度的分布情况,统计患儿治疗效果,观察不同疗效患儿他克莫司血药谷浓度变化及不良反应发生情况,应用Spearman相关性分析患儿他克莫司血药谷浓度与治疗疗效的相关性。【结果】不同血药谷浓度患儿性别、年龄分布比较,差异无统计学意义(P>0.05);临床给药剂量比较,差异有统计学意义(P<0.05)。97例NS患儿经治疗后,完全缓解(CR)患儿32例(32.99%),部分缓解(PR)患儿41例(42.27%),未缓解(NR)患儿24例(24.74%)。不同疗效患儿第1周、第2周、第3周他克莫司血药谷浓度比较,差异有统计学意义(P<0.05);CR患儿第1周、第2周、第3周他克莫司血药谷浓度均高于PR、NR患儿,且PR患儿高于NR患儿(P<0.05)。CR患儿不良反应发生率为53.12%,PR患儿为51.22%,NR患儿为33.33%,不同疗效患儿不良反应发生率比较,差异无统计学意义(P>0.05)。Spearman相关分析显示,NS患儿治疗疗效与他克莫司血药谷浓度存在正相关(rs=0.842)。【结论】NS患儿性别、年龄对他克莫司血药谷浓度影响较小,而他克莫司给药剂量可在一定程度上影响其血药谷浓度,临床要合理降低药物带来的不良反应,需制定适宜的他克莫司血用药剂量,提升治疗安全性。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
陈军校
李娜
关键词 肾病综合征他罗利姆/类似物和衍生物血药浓度    
Abstract:【Objective】 To analyze the monitoring results of tacrolimus blood trough concentration in children with nephrotic syndrome (NS) and its guiding significance. 【Methods】 A total of 97 children with nephrotic syndrome were selected as the study object. All the children were treated with tacrolimus, and their drug use was recorded. Their gender, age, dosage and distribution of different blood trough concentrations were analyzed. Their treatment effects were statistically analyzed. The changes of blood trough concentrations of tacrolimus and adverse reactions in children with different therapeutic effects were observed, Spearman correlation analysis was used to explore the correlation between the blood trough concentration of tacrolimus and the therapeutic effect in children.【Results】 There was no significant difference in gender and age distribution of children with different blood drug concentration (P>0.05); The difference in clinical dosage was statistically significant (P<0.05). After treatment in 97 children with NS, there were 32 patients with CR (32.99%), 41 patients with PR (42.27%), and 24 patients with NR (24.74%). There was a statistically significant difference in the blood concentration of tacrolimus in the first, second and third weeks of children with different therapeutic effects (P<0.05); The trough concentration of tacrolimus in children with CR at week 1, 2 and 3 was higher than that in children with PR and NR, and that in children with PR was higher than that in children with NR (P<0.05). The incidence of adverse reactions in children with CR was 53.12%, that in children with PR was 51.22%, and that in children with NR was 33.33%. There was no significant difference in the incidence of adverse reactions in children with different therapeutic effects (P>0.05). Spearman correlation analysis showed that there was a positive correlation between the therapeutic effect of NS children and the blood trough concentration of tacrolimus (rs=0.842). 【Conclusion】 The sex and age of children with nephrotic syndrome have little influence on the blood trough concentration of tacrolimus, and the dosage of tacrolimus can affect the blood trough concentration to a certain extent. To reasonably reduce the adverse reactions caused by drugs in clinical practice, it is necessary to formulate appropriate dosage of tacrolimus blood to improve the safety of treatment.
Key wordsNephrotic Syndrome    Tacrolimus/AA    Plasma Concentration
收稿日期: 2022-01-20     
中图分类号:  R692  
通讯作者: *E-mail:66189601@qq.com   
引用本文:   
陈军校, 李娜. 肾病综合征患儿他克莫司血药谷浓度监测结果分析[J]. 医学临床研究, 2022, 39(10): 1463-1465.
CHEN Jun-xiao, LI Na. Analysis of Monitoring Results of Tacrolimus Blood Trough Concentration in Children with Nephrotic Syndrome. JOURNAL OF CLINICAL RESEARCH, 2022, 39(10): 1463-1465.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.10.007     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I10/1463
版权所有 © 2013 医学临床研究杂志社  湘ICP备13012052号-1
办公地址:湖南省长沙市芙蓉区新军路43号煤炭大院主办公楼6楼621、623、632、636室 邮编:410011 电话(传真):0731-84824007 E-mail:jcr_cs.hn@vip.163.com
技术支持:北京玛格泰克科技发展有限公司 技术支持:support@magtech.com.cn