Abstract：【Objective】To explore the efficacy of Lugua polypeptide injection in the treatment of knee osteoarthritis (KOA).【Methods】A total of 110 patients with KOA in our hospital were randomly divided into the observation group and the control group,with 55 cases in each group.The control group was treated with routine therapy,while the observation group was treated with intra-articular injection of Lugua polypeptide on the basis of the control group.The total effective rate,Lequesne score,laboratory related indexes (ESR,CRP,COX-2,IL-6),the level of interleukin-18 (IL-18),and matrix metalloproteinase-13 (MMP-13) in synovial fluid were compared between the two groups after treatment.【Results】The total effective rate of the observation group was significantly higher than that of the control group (P<0.05).The scores of pain or discomfort,morning stiffness or pain after getting up,discomfort during walking,maximum walking distance and daily activity score in the two groups after treatment were significantly lower than those before treatment (P<0.05),and the above scores in the observation group after treatment were significantly lower than those in the control group (P<0.05).The levels of serum ESR,CRP,COX-2 and IL-6 in the two groups after treatment were significantly lower than those before treatment (P<0.05),and the levels of the above indicators in the observation group after treatment were significantly lower than those in the control group (P<0.05).After treatment,the levels of IL-18 and MMP-13 in synovial fluid of the two groups were significantly lower than those before treatment (P<0.05),and their levels in the observation group were significantly lower than those in the control group (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).【Conclusion】Lugua polypeptide injection has a significant effect in the treatment of KOA,which can improve relevant symptoms and laboratory indicators,reduce the levels of IL-18 and MMP-13 in synovial fluid.The incidence of adverse reactions has not increased significantly.
[1] 刘帅,白伦浩.转化生长因子超家族在骨性关节炎软骨细胞退变中的作用[J].中国矫形外科杂志,2021,29(2):140-144.
[2] BELO J N,BERGER M Y,KOES B W,et al.The prognostic value of the clinical ACR classification criteria of knee osteoarthritis for persisting knee complaints and increase of disability in general practice[J].Osteoarthritis Cartilage,2019,17(10):1288-1292.
[3] 陈李专,陈斌,林安阳,等.膝骨关节炎中西医疗法的临床研究进展[J].辽宁中医杂志,2020,47(2):203-206.
[4] LUNDEBERG T C.Physical exercise and acupuncture in the treatment of knee osteoarthritis-Not both-but maybe either one of them[J].BMJ,2021,27(39):14.
[5] NOURANI B,RABAGO D.Musculoskeletal rehabilitation (na segal,section editor) prolotherapy for knee osteoarthritis:a descriptive review[J].Curr Phys Med Rehabil Rep,2019,4(1):42-49.
[6] 中华医学会骨科学分会关节外科学组.骨关节炎诊疗指南(2018年版)[J].中华骨科杂志,2018,38(12):705-715.
[7] 向成浩,范成龙,覃文婕,等.关节镜下清理联合富血小板血浆注射治疗Kellgren-Lawrence分级Ⅰ-Ⅲ级膝骨关节炎[J].中国骨伤,2022,35(1):26-32.
[8] RADILUSTYASARI T,LEONAS R.Accuracy test of lequesne index for radiology imaging in genu osteoarthritis[J].Sriwijaya J Surg,2019,2(1):41-49.
[9] 吕娜,程鹏,夏继秀,等.针刺联合艾灸对膝骨关节炎患者血清基质金属蛋白酶及其抑制物的影响[J].针刺研究,2022,47(3):262-267.
[10] RAEISSADAT S A,AHANGAR A G,RAYEGANI S M,et al.Platelet-Rich plasma-derived growth factor vs hyaluronic acid injection in the individuals with knee osteoarthritis:A one aear randomized clinical trial[J].J Pain Res,2020,13(10):1699-1711.
[11] 王平,张清,黎元元,等.基于复杂网络分析真实世界中鹿瓜多肽注射液治疗骨折的联合药物[J].辽宁中医杂志,2021,48(7):23-28.
[12] 刘兴兴,黎元元,魏戌,等.鹿瓜多肽注射液治疗3071例骨关节炎真实世界疗效分析[J].世界中医药,2021,16(7):1126-1133.
[13] 张斌,代凤雷,尹宏,等.地黄梓醇干预早期膝骨关节炎大鼠膝关节滑膜组织中炎症相关因子的表达[J].中国组织工程研究,2020,24(29):4656-4661.
[14] 陈志伟,申建军,王泽鑫,等.陇中骨刺膏对膝关节骨性关节炎患者血清COMP、MMP-13水平的影响[J].中华中医药杂志,2021,36(1):592-595.
2022, Vol. 39 
