Abstract：【Objective】To explore the value of combined detection of multiple tumor markers in the early diagnosis of postoperative recurrence of ovarian cancer. 【Methods】A total of 104 patients with ovarian cancer suspected of recurrence in the pelvic and abdominal cavity who were admitted to our hospital from January 2016 to February 2019 were selected as the research subject. Serum carcinoembryonic antigen (CEA) was determined by electrochemiluminescence immunoassay. Levels of carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199) and serum human epididymal protein 4 (HE4) were determined by enzyme-linked immunosorbent assay. The ROC curve was used to calculate the area under the curve (AUC) and to analyze the diagnostic value of the independent and combined detection of serum CEA, HE4, CA125, and CA199 for the recurrence of ovarian cancer. 【Results】Of 104 patients with suspected pelvic and abdominal cavity recurrence, a total of 80 patients were confirmed pathologically with pelvic and abdominal cavity recurrence, and 24 patients did not relapse. CEA, CA125, and CA199 levels of patients with pelvic and abdominal cavity recurrence were higher than those of non-recurring patients (P<0.05). The AUC of the combined detection of recurrence and metastasis of ovarian cancer was 0.950, the sensitivity was 95.71%, the specificity was 80.00%, and the positive likelihood ratio was 4.79, which was significantly higher than the single detection of each index (P<0.05). 【Conclusion】The combined detection of serum CEA, HE4, CA125, and CA199 can effectively improve the diagnosis rate and has very important diagnostic significance for early recurrence of ovarian cancer.
陈燕, 郭玉格. 多种肿瘤标志物联合检测对卵巢癌术后复发的早期诊断价值[J]. 医学临床研究, 2021, 38(8): 1149-1151.
CHEN Yan, GUO Yu-ge. Predicting Value of Combined Detection of Multiple Tumor Markers in the Early Diagnosis of Postoperative Recurrence of Ovarian Cancer. JOURNAL OF CLINICAL RESEARCH, 2021, 38(8): 1149-1151.
[1] 张娟玲. 血清肿瘤标志物CA125及18F-FDG PET/CT造影在卵巢癌复发早期诊断中的价值[J].临床医学研究与实践, 2019, 4(8):89-91.
[2] 刘静, 曲芃芃. 人附睾分泌蛋白4,糖链多肽抗原125联合卵巢恶性肿瘤风险预测模型对上皮性卵巢癌预测和诊断价值[J].中国实用妇科与产科杂志, 2015,31(7):649-652.
[3] ZHEN L E, QU J Y, HE F . The diagnosis and pathological value of combined detection of HE4 and CA125 for patients with ovarian cancer[J].Open Med,2016, 11(1):125-132.
[4] 张瑜, 李馨, 骆雯,等. 联合检测血清肿瘤标志物对结肠癌根治术后患者复发转移的预测价值[J].重庆医学, 2015, 43(26):3616-3617.
[5] 张曦匀,帕提曼?米吉提,古扎丽努尔?阿不力孜.常用肿瘤标志物在上皮性卵巢癌诊断中的临床价值[J].中国现代医学杂志,2017,27(15):62-67.
[6] ZHRNG S, YANG Z, CHEN Y, et al. Correction: Simultaneous and combined detection of multiple tumor markers for cancer screening in human serum by an upgraded photonic crystal-encoded suspension array[J].RSC Adv,2016, 6(98):96202.
[7] 张瑜, 李馨, 骆雯,等. 联合检测血清肿瘤标志物对结肠癌根治术后患者复发转移的预测价值[J].重庆医学, 2015,43(26):22-23.
[8] 戎荣, 程义壮, 沈佐君. 四种血清肿瘤标志物联合检测在肺癌诊断中的价值[J].山东医药, 2018, 58(1):78-80.
[9] 梁楠楠, 林琳, 郗轶楠. 紫杉醇与卡铂联合参麦注射液对中晚期卵巢癌患者外周血T细胞亚群及血清标志物变化的影响[J].中国肿瘤临床与康复, 2018,24(3):302-305.
[10] ISHI H, YAMAMURA H, TATSUTA M, et al. Value of ultrasonographic examination combined with measurement of serum tumor markers in the diagnosis of pancreatic cancer of less than 3 cm in diameter[J].Cancer,2015, 57(10):1947-1951.
[11] 汪涛, 吕遐智, 王萍,等. 紫杉醇联合卡铂治疗卵巢癌的临床疗效及对患者血清CA125、CA199、CEA水平的影响[J].现代生物医学进展, 2018, 18(18):207-210.
[12] 冯安萍, 李波, 胡海燕,等. 联合检测血清HE4和CAl25在卵巢癌早期诊断中的意义[J].重庆医学, 2017,45(46):265-266.
2021, Vol. 38 
