补肾健脾安胎汤联合地屈孕酮片口服治疗妊娠早期肾虚型高龄先兆流产孕妇对母婴结局及生活质量的影响

doi:10.3969/j.issn.1671-7171.2021.09.012

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摘要【目的】探讨补肾健脾安胎汤联合地屈孕酮片口服治疗妊娠早期肾虚型高龄先兆流产孕妇对母婴结局及生活质量的影响。【方法】选取2018年2月至2019年11月在北京市中西医结合医院诊治的肾虚型高龄先兆流产孕妇114例,按照随机数表法分为对照组和观察组,每组57例。对照组采用地屈孕酮片口服治疗,观察组在对照组基础上加用补肾健脾安胎汤治疗,比较两组疗效、激素水平、母婴结局、生活质量。【结果】观察组患者总有效率为89.47%(51/57),显著高于对照组的70.18%(40/57),其差异有统计学意义(χ²=6.591,P=0.01)。治疗前,两组患者的E₂、HCG、P水平比较差异无统计学意义(P>0.05);治疗后,两组患者雌二醇(E₂)、血人绒毛膜促性腺激(HCG)、孕酮(P)水平显著高于治疗前,且观察组高于对照组,其差异均有统计学意义(P<0.05)。观察组患者足月妊娠率显著高于对照组,其差异有统计学意义(P<0.05);但两组患者早产率、流产率比较差异无统计学意义(P>0.05)。观察组患者治疗后心理健康、情感角色、躯体功能、社会功能、健康状态、生活力、肌体疼痛、躯体角色评分均显著高于对照组,其差异均有统计学意义(P<0.05)。【结论】补肾健脾安胎汤联合地屈孕酮片口服治疗妊娠早期肾虚型高龄先兆流产孕妇,可显著缓解患者的临床症状,补肾健脾、养血益气,提高患者激素水平、足月生产率和生活质量,值得临床推广应用。

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	张玉洁
	祁志荣
	张雪英

关键词 ：妊娠初期, 肾虚, 流产,先兆/治疗, 地屈孕酮/治疗应用, 安胎, 妊娠结局

Abstract：【Objective】To explore the effect of Bushen Jianpi Antai decoction combined with didroxyprogesterone tablets on maternal and infant outcome and quality of life in elderly threatened abortion with kidney deficiency in early pregnancy. 【Methods 】 A total of 114 elderly threatened abortion pregnant women with kidney deficiency diagnosed and treated in Beijing integrated traditional Chinese and Western medicine hospital from February 2018 to November 2019 was randomly divided into control group and observation group, with 57 cases in each group. The control group was treated with didroxyprogesterone tablets, and the observation group was treated with Bushen Jianpi Antai Decoction on the basis of the control group. The curative effects, hormone levels, maternal and infant outcomes and quality of life of the two groups were compared. 【Results】The total effective rate in the observation group was 89.47% (51/57), which was significantly higher than 70.18% (40/57) in the control group(χ²=6.591,P=0.01). Before treatment, there was no significant difference in E₂, HCG and P levels between the two groups (P>0.05); After treatment, the levels of E₂, HCG and P in the observation group were significantly higher than those in the control group (P<0.05). The full-term pregnancy rate in the observation group was significantly higher than that in the control group (P<0.05); However, there was no significant difference in preterm birth rate and abortion rate between the two groups (P>0.05). After treatment, the scores of mental health, emotional role, physical function, social function, health status, vitality, body pain and physical role in the observation group were significantly higher than those in the control group (P<0.05). 【Conclusion 】 Bushen Jianpi Antai decoction combined with didroxyprogesterone tablets can significantly alleviate the clinical symptoms of elderly threatened abortion pregnant women with kidney deficiency in early pregnancy, tonify the kidney and spleen, nourish blood and Qi, and improve the hormone level, full-term productivity and quality of life of patients. It is worthy of clinical application.

Key words： Pregnancy Trimester, First KIDNEY DEFICIENCY Abortion, Threatened/TH Dydrogesterone/TU MISCARRIGE PREVENTION Pregnancy Outcome

收稿日期: 2021-05-10

中图分类号:

R714.2

通讯作者: *E-mail:sn4iq19@163.com

引用本文:

张玉洁, 祁志荣, 张雪英. 补肾健脾安胎汤联合地屈孕酮片口服治疗妊娠早期肾虚型高龄先兆流产孕妇对母婴结局及生活质量的影响[J]. 医学临床研究, 2021, 38(9): 1321-1323.
ZHANG Yu-jie, QI Zhi-rong, ZHANG Xue-ying. Effect of Bushen Jianpi Antai Decoction Combined with Didroxyprogesterone Tablets on Maternal and Infant Outcome and Quality of Life in Elderly Threatened Abortion with Kidney Deficiency in Early Pregnancy. JOURNAL OF CLINICAL RESEARCH, 2021, 38(9): 1321-1323.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.09.012 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I9/1321