Abstract：【Objective】To explore the protective effect of lidocaine combined with lung protective ventilation on tourniquet-induced lower limbs ischemia-reperfusion lung injury. 【Methods】A total of 108 patients undergoing unilateral lower extremity surgery admitted to the hospital from June 2019 to May 2020 were selected and divided into the control group and the observation group according to a random number table, with 54 cases in each group. Both groups were treated with combined spinal-epidural anesthesia, and lung-protective ventilation were given throughout the course. While the combined group received intravenous lidocaine and the control group received the same amount of normal saline instead. The blood pressure, heart rate, alveolar artery partial pressure of oxygen (A-aDO2), oxygenation index (OI), plasma malondialdehyde (MDA), interleukin-8 (IL-8), thromboxane B2 (TXB2) levels and adverse reactions of the two groups of patients at different time points were compared. 【Results】 The average arterial pressure at 5 minutes after loosening the tourniquet (T1) in the two groups were reduced. While the average arterial pressure at T1 and 30 minutes after loosening the tourniquet (T2) in the observation group were higher than that in the control group (P<0.05). The A-aDO2 increased at T1 and T2 in the two groups, and A-aDO2 at T1 and T2 in the observation group were lower than that in the control group (P<0.05). The OI at T1 and T2 of the two groups decreased, however, the OI at T1 and T2 of the observation group were higher than that of the control group (P<0.05). The MDA, IL-8 and TXB2 of the two groups increased at T1, and the MDA, IL-8 and TXB2 of the observation group were lower than those of the control group at T1 and T2 (P<0.05). There were no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】Lidocaine combined with lung protective ventilation can reduce the tourniquet-induced lower limbs ischemia-reperfusion lung injury, and it has a certain protective effect.
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2021, Vol. 38 
