Abstract：【Objective】 To investigate the effect of MiR-221-3p expression on restenosis among patients with lower extremity arteriosclerosis obliterans (LEASO). 【Methods】 The expression of mir-221-3p in serum was detected by quantitative real-time PCR in 206 patients with leaso from March 2016 to September 2018, and their restenosis was followed up. The working characteristic curve (ROC) of subjects was drawn and the predictive value of MiR-221-3p was evaluated. The risk factors of restenosis were analyzed by multivariate regression. 【Results】 In the follow-up of 6 months after interventional therapy, there were 40 restenosis cases (restenosis group) and 166 non restenosis cases (non restenosis group). The expression level of MiR-221-3p in the restenosis group was higher than that in the non restenosis group, and the proportion of age, BMI, LDL-C, diabetes, hypertension and coronary heart disease in the restenosis group was higher than that in the non restenosis group (P<0.05). The best critical point for MiR-221-3p to predict restenosis was 0.6, and the area under AUC curve was 0.62. The sensitivity and specificity of MiR-221-3p were 52.5% and 71.1%, respectively. Cox multivariate regression analysis showed that older age, obesity, hypertension, diabetes, coronary heart disease and high expression of MiR-221-3p (≥ 0.6) increased the risk of restenosis after interventional therapy (P<0.05).【Conclusion】 The expression level of MiR-221-3p is an independent risk factor for restenosis after interventional therapy in patients with leaso. The risk of restenosis is high in patients with increased expression of MiR-221-3p.
柏友谊. MiR-221-3p与下肢动脉硬化闭塞症介入治疗后发生再狭窄的相关性[J]. 医学临床研究, 2021, 38(4): 586-588.
BAI You-yi. Relationship between MiR-221-3p and Restenosis after Interventional Therapy for Arteriosclerosis Obliterans of Lower Extremities. JOURNAL OF CLINICAL RESEARCH, 2021, 38(4): 586-588.
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