Effect of Penehyclidine Hydrochloride Combined with Continuous Renal Replacement Therapy on Patients with Acute Severe Organophosphorus Pesticide Poisoning
DUAN Wang-wang, LEI Jie-yu
Department of Clinical Medicine,Affiliated Hospital of Yan'an University,Yan'an 716000
Abstract：【Objective】 To explore the therapeutic effect of penehyclidine hydrochloride combined with continuous renal replacement therapy (CRRT) in patients with acute and severe organophosphorus pesticide poisoning. 【Methods】 A total of 60 patients with acute severe organophosphorus pesticide poisoning in our hospital were randomly divided into observation group and control group, 30 cases in each group. The control group was treated with penehyclidine hydrochloride, while the observation group was treated with CRRT on the basis of penehyclidine hydrochloride. 【Results】 The survival rate of the observation group (93.33%) was higher than that of the control group (80%) (P>0.05); the recovery time of recovery time and whole blood cholinesterase activity of the observation group were significantly shorter than those of the control group (P<0.05); after treatment, the levels of C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) in the two groups were significantly lower than those at admission (P<0.05), and the levels of CRP and TNF-α in the observation group were significantly lower than those in the control group (P<0.05) 【Conclusion】 Penehyclidine hydrochloride combined with CRRT has good curative effect in the treatment of patients with organophosphorus pesticide poisoning, which can effectively remove the inflammatory factors, shorten the recovery time of patients and the recovery time of whole blood cholinesterase activity, and improve the therapeutic effect.
[1] HULSE E J, DAVIES J O J,SIMPSON A J, et al. Respiratory complications of organophosphorus nerve agent and insecticide poisoning. Implications for respiratory and critical care[J].Am J Respir Crit Care Med,2014, 190(12):1342-1354. [2] 李玉萍.盐酸戊乙奎醚治疗有机磷农药中毒临床疗效[J].中国药物与临床,2018,18(z1):64-65. [3] 李媛媛,苟欣鹏.血液灌流联合连续性肾脏替代治疗对急性有机磷农药中毒患者炎性因子水平及治疗效果临床观察[J].山西医药杂志,2020,49(3):273-275. [4] 中国医师协会急诊医师分会.急性有机磷农药中毒诊治临床专家共识(2016)[J].中国急救医学,2016,36(12):1057-1065. [5] 钱贝丽,韩若东,颜秀侠.急性重度有机磷中毒96例认知障碍影响因素临床研究[J].安徽医药,2020,24(4):684-687. [6] 石俊生,任冬,许凌峰.长托宁联合阿托品治疗急性重度有机磷中毒的临床应用[J].中国急救医学,2016,36(z1):130-131. [7] 于续芳,黄占东.连续性肾脏替代治疗治疗急性重度有机磷农药中毒伴重度脑病[J].中国药师,2014,(2):273-274. [8] LI ZH,WANG GX,ZHEN GD,et al. Application of hemoperfusion in severe acute organophosphorus pesticide poisoning[J].Turk J Med Sci,2017, 47:1277-1281. [9] LIU L, DING G. Effects of different blood purification methods on serum cytokine levels and prognosis in patients with acute severe organophosphorus pesticide poisoning[J].Ther Apher Dial,2015, 19(2):185-190.
2021, Vol. 38 
