法舒地尔对急性脑梗死患者血清MMP-10、ox-LDL及GSH-Px的影响

doi:10.3969/j.issn.1671-7171.2021.02.023

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摘要 【目的】 探讨法舒地尔治疗急性脑梗死(ACI)的疗效及对患者血清基质金属蛋白酶10 (MMP-10)、氧化低密度脂蛋白(ox-LDL)及谷胱甘肽过氧化物酶(GSH-Px)水平的影响。【方法】 本院收治的100例ACI患者,随机分为观察组和对照组,各50例。对照组采用常规治疗,观察组在对照组基础上增加法舒地尔治疗,比较两组治疗后的血清指标水平变化、神经功能缺损程度、生活活动能力、临床疗效以及安全性。【结果】 治疗后观察组总有效率为90%(45/50),明显高于对照组的64%(32/50),且两组相比较差异有显著性(P<0.05);两组NIHSS评分明显降低,ADL评分明显上升,观察组的NIHSS评分低于对照组,ADL评分高于对照组(P<0.05);两组治疗后血清MMP-10、ox-LDL、GSH-Px水平明显降低,且观察组较对照组降低更为显著(P<0.05)。观察组无药物不良反应发生,患者的耐受性较好。【结论】 在常规治疗上增加使用法舒地尔,能降低ACI患者血清MMP-10、ox-LDL及GSH-Px水平,改善患者的神经功能缺损程度,提高患者日常生活能力,其疗效显著,无不良反应发生,安全性较高,值得临床推广应用。

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	沈育桦
	阮琼艳
	杨祺

关键词 ：脑梗死, 急性病, 血管舒张药/治疗应用, 基质金属蛋白酶10 /血液, 脂蛋白类,LDL/血液

Abstract：【Objective】 To investigate the effects of fasudil on MMP-10 (matrix metalloproteinase 10), ox-LDL (ox-LDL) and GSH-Px (glutathione peroxidase) in patients with acute cerebral infarction(ACI). 【Methods】 A total of 100 patients with ACI in our hospital were randomly divided into two groups, each group with 50 cases. Patients with conventional treatment were as the control group, while patients in the observation group received fasudil in addition to the conventional treatment. Serum index levels, neurologic impairment, life activity, clinical efficacy and safety of the two groups were compared. 【Results】 After treatment, the total effective rates for the observation group and the control group were 90% and 64%, respectively. The efficiency of the observation group was significantly higher than that of the control group; the difference was statistical significance (P<0.05). The NIHSS score in the two groups decreased significantly, and the ADL score increased significantly in the two groups as well. However, the NIHSS score in the observation group was lower than that in the control group, ADL score in the observation group was higher than that in the control group; the difference was statistical significance (P<0.05). After treatment, serum MMP-10, ox-LDL and GSH-Px levels were significantly reduced in the two groups, and the reduction level of the observation group was significantly lower than that of the control group (P<0.05). There was no adverse drug effects in the observation group showing good tolerance after treatment. 【Conclusion】 The use of fasudil on the basis of conventional treatment in the clinical treatment of ACI can reduce serum MMP-10, ox-LDL and GSH-Px levels and improve the ability of daily life. It has significant curative effect, no adverse reaction and high safety, which is worthy of clinical application.

Key words： Brain Infarction Acute Disease Vasodilator Agents/TU Matrix Metalloproteinase 10/BL Lipoproteins, LDL/BL

收稿日期: 2019-05-10

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R743.33

通讯作者: *E-mail:305780476@qq.com

引用本文:

沈育桦, 阮琼艳, 杨祺. 法舒地尔对急性脑梗死患者血清MMP-10、ox-LDL及GSH-Px的影响[J]. 医学临床研究, 2021, 38(2): 240-242.
SHEN Yu-hua, RUAN Qiong-yan, YANG Qi. Effects of Fasudil on Serum Levels of MMP-10, ox-LDL and GSH-Px in Patients with Acute Cerebral Infarction. JOURNAL OF CLINICAL RESEARCH, 2021, 38(2): 240-242.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.02.023 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I2/240