Abstract：【Objective】To explore the influence of pathogenic bacteria distribution on fracture healing in patients with open tibial fracture wound infection. 【Methods】From June 2016 to June 2019, 92 patients with open tibial fracture wound infection were selected as the research objects. The pathogenic bacteria of the infected exudates were identified, and the corresponding internal fixation treatment was taken according to the patients' own situation. All the patients were followed up 6 months after operation, and the factors that may affect the fracture healing were collected and analyzed. The factors that may affect the fracture healing were analyzed by logistic regression analysis. 【Results】A total of 119 strains of pathogenic bacteria were isolated from 92 patients with open tibial fracture. Among them, 79 strains were Gram-negative bacteria, mainly Escherichia coli, accounting for 40.34%; 40 strains were Gram-positive bacteria, mainly Staphylococcus aureus, accounting for 16.81%. All 92 cases were followed up for 6 months, 69 cases healed, the rate of fracture healing was 75.00%. The single factor analysis showed that the factors influencing fracture healing were related to age, fracture cause, fracture type, time from injury to treatment and time of soft tissue repair (P<0.05). Multivariate logistic regression analysis showed that: age ≥60 years old, high-energy injury, fracture type III, fracture type II, injury to treatment time ≥ 6 h and secondary repair of soft tissue were independent risk factors (OR=2.72, 3.36, 3.37, 1.26, 2.16, 2.37, P<0.05). 【Conclusion】Escherichia coli is the main pathogen of open tibial fracture wound infection. In addition, age ≥ 60 years old, high-energy injury, high fracture classification, time from injury to treatment ≥ 6h and secondary repair of soft tissue are independent risk factors for fracture healing in patients with open tibial fracture wound infection. Pre-measures should be taken to reduce the risk of delayed wound healing and promote the early recovery of patients.
张华, 路倩, 乔荣芳. 开放性胫骨骨折创面感染患者病原菌分布情况及骨折愈合的影响因素分析[J]. 医学临床研究, 2021, 38(6): 886-889.
ZHANG Hua, LU Qian, QIAO Rong-fang. Influence of Pathogenic Bacteria Distribution on Fracture Healing in Patients with Open Tibial Fracture Wound Infection. JOURNAL OF CLINICAL RESEARCH, 2021, 38(6): 886-889.
2021, Vol. 38 
