医学临床研究
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医学临床研究  2021, Vol. 38 Issue (6): 883-885    DOI: 10.3969/j.issn.1671-7171.2021.06.022
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甲磺酸阿帕替尼片治疗晚期胃癌的疗效
刘甫, 马沛, 魏海
河南省南阳市第一人民医院胃肠外一科,河南 南阳 473000
Efficacy of Apatinib Mesylate Tablets in the Treatment of Advanced Gastric Cancer
LIU Fu, MA Pei, WEI Hai
The First Department of Gastrointestinal Surgery, Nanyang First People's Hospital, Nanyang, Henan 473000
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摘要 【目的】观察甲磺酸阿帕替尼片治疗晚期胃癌的疗效,为临床治疗提供参考。【方法】选取本院收治的经一线化疗(FOLFOX方案)方案治疗后进展的晚期胃癌患者70例,随机分为两组,对照组35例给予替吉奥治疗,观察组35例给予甲磺酸阿帕替尼片治疗,比较两组患者治疗后的临床疗效。【结果】观察组完全缓解1例,部分缓解15例,客观缓解率为45.71%(16/35),对照组完全缓解0例,部分缓解14例,客观缓解率为40.00%(14/35);两组患者客观缓解率比较差异无显著性(P>0.05)。两组治疗前干扰素-γ(INF-γ)、白细胞介素-4(IL-4)、血清糖链抗原19-9(CA19-9)、糖链抗原72-4(CA72-4)水平组间比较差异均无显著性(P>0.05)。治疗后,两组患者INF-γ水平较治疗前升高,IL-4、CA19-9、CA72-4水平较治疗前下降,且观察组治疗后INF-γ、IL-4、CA19-9、CA72-4水平优于对照组(P<0.05)。观察组高血压发生率(22.86%)高于对照组(5.71%),腹泻发生率(11.43%),恶心呕吐发生率(8.57%)、手足综合征发生率(2.86%)、中性粒细胞减少发生率(0.00%)均低于对照组(31.43%、11.43%、5.71%、5.71%),且差异有显著性(P<0.05)。【结论】甲磺酸阿帕替尼片和替吉奥治疗晚期胃癌疗效相近,甲磺酸阿帕替尼片对相关细胞因子改善更加明显,但应注意高血压的发生。
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刘甫
马沛
魏海
关键词 胃肿瘤/药物疗法抗肿瘤药/治疗应用治疗结果    
Abstract:【Objective】To observe the efficacy of apatinib mesylate tablets in the treatment of advanced gastric cancer and to provide reference for clinical treatment. 【Methods】A total of 70 patients with advanced gastric cancer after first-line chemotherapy (FOLFOX regimen) were randomly divided into two groups. The control group was treated with tigio and the observation group was treated with apatinib mesylate tablets. The clinical efficacy of the two groups after treatment was analyzed. 【Results】In the observation group, there was 1 case of complete remission and 15 cases of partial remission. The objective remission rate was 45.71%. There were 0 cases of complete remission in the control group and 14 cases of partial remission. The objective remission rate was 40.00% (14/35). There was no significant difference in the objective remission rate between the two groups (P>0.05). There was no significant difference in the levels of interferon-gamma (INF- γ), IL-4 (IL-4), serum sugar chain antigen 19- 9 (CA19-9), and sugar chain antigen 72 -4 (CA72-4) between the two groups before treatment (P>0.05). After treatment, the levels of INF- γ and IL-4, CA19-9, CA72-4 in the two groups were higher than those before treatment, and the levels of INF- γ and IL-4, CA19-9, and CA72-4 in the observation group were better than those in the control group after treatment (P<0.05). The incidence of hypertension (22.86%) was higher in the observation group than in t the control group (5.71%), the incidence of diarrhea (11.43%) was lower than that in the control group (31.43%), and the incidence of nausea and vomiting (8.57%), hand and foot syndrome (2.86%), and neutropenia (0.00%) were lower than those of the control group (11.43%, 5.71%, 5.71%, respectively). The difference was statistically significant (P<0.05). 【Conclusion】Apatinib mesylate tablets and tigio tablets have similar efficacy in the treatment of advanced gastric cancer. Apatinib mesylate tablets have more obvious improvement on related cytokines, but attention should be paid to the occurrence of hypertension.
Key wordsStomach Neoplasms/DT    Antineoplastic Agents/TU    Treatment Outcome
收稿日期: 2019-10-15     
中图分类号:  R735.2  
引用本文:   
刘甫, 马沛, 魏海. 甲磺酸阿帕替尼片治疗晚期胃癌的疗效[J]. 医学临床研究, 2021, 38(6): 883-885.
LIU Fu, MA Pei, WEI Hai. Efficacy of Apatinib Mesylate Tablets in the Treatment of Advanced Gastric Cancer. JOURNAL OF CLINICAL RESEARCH, 2021, 38(6): 883-885.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.06.022     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I6/883
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