Abstract：【Objective】To reveal the clinical significance of helicobacter pylori (Hp) antibody IgG (HpIgG) detection in saliva and Hp antigen in feces of patients with chronic gastritis. 【Methods】The patients with chronic gastritis who were treated in our hospital were selected as the observation group and healthy adults who had physical examination in our hospital during the same period were selected as the control group. The results of HpIgG in saliva and Hp antigen in feces of the two groups were observed. The differences of pepsinogen (PGⅠ and PGⅡ), G-17 (gastrin 17), cytokine hypersensitive C-reaction protein(hs-CRP) and cytokines (IL-18 and IL-6) levels between the two groups were compared. The correlation between the results of HpIgG in saliva and Hp antigen in feces of patients with chronic gastritis and the levels of PGⅠ, PGⅡ, G-17 and cytokines was analyzed. 【Results】In the observation group, the positive rates of HpIgG in saliva and Hp antigen in feces were 72.00% and 45.00%, respectively, which were higher than those in the control group (P<0.01). The levels of PGⅠ and PGⅡ in the observation group were lower than those in the control group, while the level of G-17 in the observation group was higher than that in the control group (P<0.01). The levels of IL-18, IL-6 and hs-CRP in the observation group were higher than those in the control group (P<0.01). The positive rates of HpIgG in saliva and Hp antigen in feces of patients in the observation group were negatively correlated with the levels of PGⅠ and PGⅡ, and positively correlated with the levels of G-17, IL-18, IL-6 and hs-CRP (P<0.05). 【Conclusion】The positive rate of HpIgG in saliva and Hp antigen in feces is higher in patients with chronic gastritis, and it is related to pepsin and cytokine levels.
2021, Vol. 38 
