Abstract：【Objective】To investigate the correlation between serum bilirubin level and mortality in peritoneal dialysis(PD) patients and analyze its predictive value for prognosis of PD patients. 【Methods】A total of 140 patients with maintenance PD in our hospital from May 30, 2015 to May 30, 2017 were selected for the study. The blood bilirubin level was measured at 6 months of dialysis. The baseline clinical data and laboratory results were recorded. The termination time of follow-up was May 30, 2019, and the end point of follow-up was all-cause death. The ROC curve were used to determine the best cut-off point of blood bilirubin. The correlation between blood bilirubin and death were revealed and its predictive value for mortality were analyzed. 【Results】The follow-up time was 6-42 months and the median follow-up time was 34 months. A total of 33 patients died. The average level of blood bilirubin was (5.3 ± 1.4) μmol/L. The area under the ROC curve (AUC) of blood bilirubin predicted all-cause mortality was 0.69 (p=0.012), the best cut-off point of blood bilirubin was 3.3 μmol/L, the sensitivity was 67.5%, and the specificity was 69.1%. There were 32 patients with bilirubin low value (<3.3 μmol/L) and 108 patients with high bilirubin group (≥3.3 μmol/L). The albumin, serum calcium and hemoglobin levels in the low bilirubin group were lower than those in the high bilirubin group (P<0.05). The cumulative survival rate of low bilirubin group was lower than that of the high bilirubin group(P<0.05) . Uric acid, blood glucose, dialysis adequacy, age, and bilirubin were independent risk factors for all-cause mortality in maintenance PD patients (P<0.05). 【Conclusion】The mortality of maintenance PD with blood bilirubin <3.3 μmol/L is high. The blood bilirubin level is an effective biomarker for predicting all-cause death in patients with PD.
安玲. 血清胆红素水平对腹膜透析患者预后的判断价值[J]. 医学临床研究, 2020, 37(11): 1634-1636.
AN Ling. Predictive Value of Serum Bilirubin Level in Patients with Peritoneal Dialysis. JOURNAL OF CLINICAL RESEARCH, 2020, 37(11): 1634-1636.
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2020, Vol. 37 
