Abstract：【Objective】 To investigate the predictive diagnostic value of thrombopoietin (TPO) and hypoxia inducible factor-1α(HIF-1α) in high-risk infants with cerebral palsy (CP).【Methods】 A total of 120 cases of CP high-risk infants was selected as the research object, and 35 cases of healthy newborns in the same period were selected as the control group. The high-risk infants were followed up until CP was diagnosed or excluded. According to the follow-up results, CP high-risk infants were divided into CP Group (n=36) and non CP Group (n=73); CP Group was divided into mild subgroup (n=14), moderate subgroup (n=10) and severe subgroup (n=12). The levels of serum TPO and HIF-1αin each group were compared, and the ROC curve was drawn to analyze the diagnostic value of serum TPO and HIF-1αfor CP. Spearman linear correlation was used to analyze the correlation between serum TPO and HIF-1αlevels in CP high-risk infants. 【Results】 The serum TPO level in CP Group was higher than that in control group but lower than that in non CP Group; there were significant differences among control group, non CP Group, CP Group and each subgroup (P<0.05). The serum HIF-1 α level in CP Group was higher than that in control group and non CP Group, and that in non CP Group was higher than that in control group. There were significant differences among control group, non CP Group, CP Group and subgroups with different disease severity (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of serum TPO in the diagnosis of CP was 0.785, the sensitivity was 77.80%, the specificity was 79.45%, and the best cut-off value was 596.75 pg / ml; the AUC of serum HIF-1αin diagnosing CP was 0.779, the sensitivity was 80.06%, the specificity was 80.56%, and the best cut-off value was 5.72 ng / ml. Spearman linear correlation analysis showed that there was a negative correlation between serum TPO and HIF-1α(r=-0.334,P<0.001).【Conclusion】 The levels of serum TPO and HIF-1αin high-risk infants with CP are higher than those in healthy newborns. The changes of serum TPO and HIF-1αlevels play an important role in the pathogenesis of CP.
杨关山, 王万丽. 促血小板生成素和缺氧诱导因子-1α对脑瘫高危儿的预测价值[J]. 医学临床研究, 2020, 37(10): 1526-1528.
YANG Guan-shan, WANG Wan-li. Predictive Value of Thrombopoietin and Hypoxia Inducible Factor-1α in High Risk Infants with Cerebral Palsy. JOURNAL OF CLINICAL RESEARCH, 2020, 37(10): 1526-1528.
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2020, Vol. 37 
