Abstract：【Objective】 To explore the expression and significance of hypoxia inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and B-cell lymphoma-2 (Bcl-2) in cervical carcinoma. 【Methods】 The expression of HIF-1α, VEGF and Bcl-2 in 82 cases of cervical carcinoma and normal cervical tissues was detected by immunohistochemical method. The relationship between the three markers (HIF-1α, VEGF and Bcl-2) and clinical pathological parameters was analyzed. 【Results】 The positive rate of HIF-1α in cervical carcinoma 80.48% (66/82) was higher than that in normal cervical tissues 2.43% (2/82) (P<0.05). The positive rate of VEGF in cervical carcinoma 82.93% (68/82) was higher than that in normal cervical tissues 3.65% (3/82) (P<0.05). The positive rate of Bcl-2 in cervical carcinoma 73.17% (60/82) was higher than that in normal cervical tissues 30.48% (25/82) (P<0.05). The positive expression rates of HIF-1α, and VEGF in cervical carcinoma with differential degree, clinical stage and lymph node metastasis were statistically significant (P<0.05), but not correlated with age, gender and lesion size. The positive expression rate of Bcl-2 wasn't related to those clinical parameters (differential degree, clinical stage, lymph node metastasis, age, gender and lesion size) (P>0.05).According to Pearson correlation analysis, HIF-1α expression was positively correlated with the expression of VEGF and Bcl-2 in cervical cancer tissues (r=0.685, P=0.010; r=0.532, P=0.025, respectively); VEGF was positively correlated with Bcl-2 expression (r=0.584, P=0.033).【Conclusion】 The high expression of HIF-1α, VEGF and Bcl-2 in cervical carcinoma can be used as reference indicators to determine the occurrence and lymph node metastasis of cervical carcinoma.
于峰, 韩超, 韩丽娜, 李莉. HIF-1α、VEGF及Bcl-2在宫颈癌组织中的表达及其意义[J]. 医学临床研究, 2018, 35(9): 1696-1698.
YU Feng, HAN Chao, HAN Li-na, et al. Significance of HIF-1α, VEGF and Bcl-2 Expression in Cervical Carcinoma. JOURNAL OF CLINICAL RESEARCH, 2018, 35(9): 1696-1698.
2018, Vol. 35 
