医学临床研究
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医学临床研究  2020, Vol. 37 Issue (3): 364-366    DOI: 10.3969/j.issn.1671-7171.2020.03.013
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血清促甲状腺素水平对2型糖尿病合并亚临床甲减患者心血管疾病发生风险的影响
张霞
无锡市第八人民医院内科,江苏 无锡 214000
Effect of Serum Thyroid Stimulating Hormone Level on Risk of Cardiovascular Disease in Patients with Type 2 Diabetes Combined with Subclinical Hypothyroidism
ZHANG Xia
Wuxi eighth people's hospital ,Wuxi Jiangsu 214000
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摘要 【目的】探讨血清促甲状腺素(TSH)水平对2型糖尿病(T2DM)合并亚临床甲减患者心血管疾病发生风险的影响。【方法】选取2014年1月至2017年1月在本院诊治的100例T2DM合并亚临床甲减的患者,根据入院时TSH水平分为TSH升高组(TSH>5.6 IU/mL,n=28)和TSH正常组(TSH≤5.6 IU/mL,n=72)。比较两组患者心血管疾病发病率,分析TSH水平与临床指标相关性,多元Logistic回归分析患者心血管事件发生的危险因素。【结果】TSH升高组游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4)水平显著低于TSH正常组,差异有统计学意义(P<0.05);TSH升高组心血管事件发生率39.29%(11/28),高于TSH正常组的13.89%(10/72),其差异有统计学意义(P<0.05)。 TSH水平与入院时收缩压呈正相关(P<0.05),与FT3、FT4呈负相关(P<0.05)。多元Logistic回归分析显示:血尿酸、收缩压、TSH、FT3、三酰甘油(TG)是心血管疾病发病的危险因素。【结论】血清TSH水平与T2DM合并亚临床甲减患者心血管疾病发病风险显著相关。
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张霞
关键词 糖尿病 2型/并发症甲状腺功能减退症/并发症促甲状腺素    
Abstract:【Objective】To investigate the effect of serum thyroid stimulating hormone levels on the risk of cardiovascular disease in type 2 diabetes patients with subclinical hypothyroidism. 【Methods】One hundred T2DM patients with subclinical hypothyroidism who were treated in our hospital from January 2014 to January 2017 were divided into two groups according to the TSH level at the time of admission: the TSH increased group (TSH > 5.6 IU/mL, n=28) and the TSH normal group (TSH ≤ 5.6 IU/mL, n=72). The incidence rate of cardiovascular disease in two groups was compared, and the correlation between TSH level and clinical index was analyzed. Multivariate Logistic regression analysis was performed to analyze the risk factors of cardiovascular events.【Results】The levels of free triiodothyronine (FT3) and free thyroxine (FT4) in the TSH increased group were significantly lower than those in the TSH normal group (P<0.05); the incidence of cardiovascular events in the TSH increased group was 39.29% (11 / 28), higher than 13.89% (10/72) in the TSH normal group (P<0.05). TSH level was positively correlated with systolic blood pressure at admission (P<0.05), and negatively correlated with FT3 and FT4 (P<0.05). Multiple logistic regression analysis showed that: uric acid, systolic blood pressure, TSH, FT3, triglyceride (TG) were the risk factors of cardiovascular disease.【Conclusion】Serum TSH levels are significantly associated with the risk of cardiovascular disease in type 2 diabetes patients with subclinical hypothyroidism.
Key wordsDiabetes Mellitus    Type 2 /CO    Hypothyroidism/CO    Thyrotropin
收稿日期: 2019-04-15     
PACS:  R587.1  
引用本文:   
张霞. 血清促甲状腺素水平对2型糖尿病合并亚临床甲减患者心血管疾病发生风险的影响[J]. 医学临床研究, 2020, 37(3): 364-366.
ZHANG Xia. Effect of Serum Thyroid Stimulating Hormone Level on Risk of Cardiovascular Disease in Patients with Type 2 Diabetes Combined with Subclinical Hypothyroidism. JOURNAL OF CLINICAL RESEARCH, 2020, 37(3): 364-366.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.03.013     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I3/364
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