Abstract：【Objective】To explore the clinical value of ropacaine nerve block in neurosurgery craniotomy.【Methods】A total of 98 patients who underwent carniotomy from October 2016 to December 2017 were randomly divided into group A and group B, with 49 cases in each group. Group A received ropacaine nerve block combined with intravenous general anesthesia, while group B only received intravenous general anesthesia. The heart rate (HR), mean arterial pressure (MAP), bispectral index (BIS) at different time points were recorded; postoperative pain (VAS) score, adverse reactions, serum substance P and serotonin (5-HT) before and after surgery were compared in the two groups. 【Results】At the time of T0~T3, there were no significant differences in values of HR, MAP and BIS between group A and the group B (P>0.05). The VAS scores at 4 h, 12 h, and 24 h after surgery in the observation group were significantly lower than those in the control group; and the difference were statistically significant (P<0.05). At 24 hours after operation, serum levels of substance P and 5-HT in group A were significantly lower than those in group B (P<0.05), though there were no significant difference before surgery. The incidence of adverse reactions in patients of group A was 6.12% (3/49) and that of group B was 12.24% (6/49), which did not show statistically significant (χ2=1.101,P=0.294>0.05).【Conclusion】 The use of ropacaine nerve block in neurosurgery craniotomy is beneficial to reduce postoperative pain and decrease serum substance P and 5-HT levels.
[1] 王云霞,王会文,侯春梅,等.神经外科患者麻醉恢复期常见并发症及危险因素分析[J].中国康复理论与实践,2016,22(8):962-967. [2] Mathur PR, Jain N, Kumar A, et al. Comparison between lignocaine nebulization and airway nerve block for awake fiberoptic bronchoscopy-guided nasotracheal intubation: a single-blind randomized prospective study[J]. Korean J Anesthesiol, 2018, 71(2):120-126. [3] 赵世凌.开颅手术应用罗哌卡因神经阻滞麻醉对血流动力学的影响分析[J].中国实用神经疾病杂志,2016,5(1):106-107. [4] 张琴琴,赵媛,孔高茵,等.头皮神经阻滞联合瑞芬太尼靶控输注在小儿开颅手术麻醉中的应用[J].临床小儿外科杂志,2016,15(6):621-624,628. [5] 王茂,梅伟.超声引导下头皮神经阻滞用于脑功能区肿瘤切除术中唤醒一例[J].临床外科杂志,2018,26(2):148-149. [6] 康青乐,李亚平.头皮神经阻滞复合七氟醚在颅脑手术中的临床应用[J].昆明医科大学学报,2016,37(12):72-75. [7] 阳垚鑫,李羽.头皮神经阻滞在小儿开颅手术中的应用[J].中华妇幼临床医学杂志(电子版),2016,5(1):118-120. [8] 贾献辉,叶常红.罗哌卡因与地佐辛联合使用对颅脑外科ASA Ⅰ、Ⅱ级患者全麻恢复期躁动的影响[J].中国生化药物杂志,2016,6(1):89-91. [9] 闫俊莲,刘宝伟,刘胜群,等.头部神经阻滞联合静脉全麻在神经外科手术麻醉中的应用价值[J].中国实用神经疾病杂志,2016,19(8):103-104. [10] Saralaya S, Adirajaiah S B, Anehosur V. 4% Articaine and 2% Lignocaine for surgical removal of third molar by mandibular nerve block: a randomized clinical trial for efficacy and safety[J]. J Maxillofac Oral Surg, 2018,15(5):1-7. [11] 金海龙,申颖,孟岚,等.神经阻滞治疗开颅术后重度颅外神经痛的效果:33例回顾性分析[J].中华麻醉学杂志,2017,37(11):1326-1328.
2020, Vol. 37 
