Abstract：【Objective】To investigate the anesthetic effect of laryngeal mask ventilation combined with intercostal nerve block anesthesia in patients undergoing modified radical mastectomy for breast cancer.【Methods】Seventy-four patients with radical mastectomy were randomly divided into two groups, 37 in each group. The control group was given laryngeal mask general anesthesia, while the observation group was given laryngeal mask ventilation combined with intercostal nerve block anesthesia. The changes of hemodynamics, stress response index and anesthesia safety before induction of anesthesia (T1), during skin incision (T2), 1 hour after skin incision (T3) and 5 minutes after removal of laryngeal mask (T4) were compared between the two groups.【Results】Systolic blood pressure (SBP) and heart rate (HR) at T3 and T4 in the observation group were lower than those in the control group (P<0.05); there was no significant difference in SBP and HR at four time points in the observation group (P>0.05); SBP and HR at T3 and T4 time points in the control group were higher than those at T1 and T2 time points (P<0.05). Cor and Ang-Ⅱ levels at T2, T3 and T4 in the observation group were lower than those in the control group (P<0.05); Ang-Ⅱ levels at T4 in the observation group were higher than those at T1 (P<0.05); Cor and Ang-Ⅱ levels at T2, T3 and T4 in the control group were higher than those at T1 (P<0.05). There was no significant difference in the incidence of perioperative adverse reactions between the two groups (P>0.05).【Conclusion】Laryngeal mask ventilation combined with intercostal nerve block anesthesia for modified radical mastectomy of breast cancer has less influence on intraoperative hemodynamics, which is helpful to reduce perioperative stress response of patients, and has high anesthesia safety. It is worth popularizing and applying.
2019, Vol. 36 
