Abstract：【Objective】To investigate the levels and significance of trilobal factor 1 (TFF1) and monocyte chemoattractant protein 1 (MCP 1) in urine of patients with renal calculi. 【Methods】From January 2017 to April 2018, 103 patients with renal calculi were selected as observation group and 100 healthy volunteers as control group, serum biochemical parameters such as serum calcium and creatinine in two groups were detected, urine TFF1, MCP-1 and urinary calcium level were detected. 【Results】There was no significant difference in serum calcium, creatinine, uric acid and urea nitrogen between the observation group and the control group (P>0.05). The levels of TFF1 in urine of the observation group were significantly lower than those of the control group, while the levels of MCP-1 and urinary calcium were significantly higher than those of the control group (P<0.05). The estimated glomerular filtration rate (eGFR) of the observation group was (88.10±32.20)[mL/(min·1.73 m2)]. The correlation analysis of urine TFF1, MCP-1, urine calcium and eGFR in the observation group showed that urine TFF1 was negatively correlated with urine calcium (r=-0.433, P<0.05), urine MCP-1 was positively correlated with urine calcium (r=0.404, P<0.05), and negatively correlated with eGFR (r=-0.362, P<0.05).【Conclusion】The level of TFF1 in urine of patients with renal calculi decreases, while the level of MCP-1 increases, which is correlated with urinary calcium and eGFR in patients with renal calculi.
张剑, 陈志强, 孙国良, 蒋泉, 于汝通, 王军. 肾结石患者尿液中TFF1、MCP-1表达水平及意义[J]. 医学临床研究, 2019, 36(9): 1745-1747.
ZHANG Jian, CHEN Zhi-qiang, SUN Guo-liang,et al. Expression of TFF1 and MCP-1 in Urine of Patients with Renal calculi and its Significance. JOURNAL OF CLINICAL RESEARCH, 2019, 36(9): 1745-1747.
[1] 孙勇,勒娟,潘晓峰,等. 肠三叶因子启动子荧光素酶报告基因载体的构建及活性分析[J].武汉大学学报(医学版),2015,36(5):823-826. [2] 张林超,孙继建,潘世杰,等. CNPs对肾结石大鼠尿液NGAL、MCP-1水平和肾功能的影响[J].东南大学学报(医学版),2017,36(5):768-772. [3] Mathiyalagen P, Neelakantan A, Balusamy K,et al.A case–control study on environmental and biological risk factors for renal calculi persisting in a coastal Union Territory, India[J].J Family Med Primary Care,2017,6(1):126-128. [4] Huynh M, Clark R, Li J,et al.A case control analysis investigating risk factors and outcomes for nephrocalcinosis and renal calculi in neonates[J].J Pediatric Urol,2017,13(4):351-356. [5] 王慧慧,金仁顺. 三叶因子家族1和细胞周期蛋白D1在胃癌组织中的表达及意义[J].中国老年学杂志,2017,37(3):660-662. [6] 王杰,粟宏伟,刘鑫,等. 钙化性纳米微粒致肾结石大鼠尿液中性粒细胞明胶酶相关脂质运载蛋白、骨桥蛋白及单核细胞趋化蛋白-1的变化及其意义[J].中国现代医学杂志,2015,25(23):1-6. [7] 王斌,陶佳意,汪兴旺,等. 肾结石患者术后泌尿系感染与结石复发的相关因素分析[J].中华医院感染学杂志,2016,26(13):3026-3027. [8] 唐桂良,李俊龙,应向荣,等. 肾结石术后泌尿系感染与结石复发的临床探讨[J].中华全科医学,2015,13(6):1027-1029. [9] 黎承杨,王扬,邓耀良. 炎症反应与肾结石形成关系研究进展[J].临床泌尿外科杂志,2015,30(12):1150-1153. [10] 孙春,黎承杨,邓耀良,等. 尿钙对含钙肾结石患者尿液MCP-1、TFF1及HMGB1生成的影响[J].广东医学,2015,36(13):2017-2021.
2019, Vol. 36 
