Abstract:【Objective】To study the efficacy and safety of single-port thoracoscopic parietal pleural resection in the treatment of pulmonary bullae.【Method】A total of 100 patients with pulmonary bullae in our hospital from February 2015 to February 2018 were selected as the study subjects.According to the random number table method, the patients were divided into observation group and control group, 50 cases each.The control group was treated with single-hole thoracoscopy for bullae, while the observation group was treated with single-hole thoracoscopy for bullae.The perioperative indexes such as operation time, hospital stay, drainage volume, time to get out of bed, recovery time, feeding time and anesthetic effect were compared between the two groups.In addition, the levels of CRP, IL-6, IL-8, TNF-alpha, FT3, FT4 and COR were compared between the two groups before operation, 1 and 2 weeks after operation.The incidence of complications and recurrence rate were observed.The changes of respiratory function before and after operation were compared between the two groups.【Result】The operation time, hospitalization time, drainage volume, time to get out of bed, recovery time and eating time of the observation group were significantly lower than those of the control group (P<0.05).The CRP, IL-6, IL-8, TNF-a, FT3, FT4 and COR in the observation group were significantly lower than those in the control group at 1 and 2 weeks after operation (P<0.05).The total incidence of complications in the two groups was significantly lower than that in the control group (P<0.05).There was no significant difference in recurrence rate between the two groups (P>0.05).The respiratory rate and PaCO2 of the two groups at 1 and 2 weeks after operation were lower than those before operation, and the PaO2 was higher than that before operation,the difference were statistically significant (P<0.05).The respiratory rate and PaCO2 at 1 and 2 weeks after operation in the observation group were lower than those in the control group, and the PaO2 was higher than that in the control group,the difference were statistically significant (P<0.05).【Conclusion】Single-port thoracoscopic parietal pleural resection is effective in the treatment of pulmonary bullae. Compared with traditional laparoscopic surgery, it can reduce the risk of complications, and is helpful for early recovery of respiratory function after operation with higher clinical value.