Abstract：【Objective】To study the therapeutic effect of two-port thoracoscopic lobectomy with systematic lymph node dissection on non-small cell lung cancer(NSCLC).【Methods】A total of 220 patients with NSCLC who were diagnosed and prepared to undergo lobectomy with systematic lymph node dissection from March 2012 to March 2014 in our department were enrolled in this study. Patients were randomly divided into the observation group and the control group. Patients in the observation group underwent two-port thoracoscopic lobectomy with systematic lymph node dissection while patients in the control group underwent routine three-port thoracoscopic lobectomy with systematic lymph node dissection. The operation duration, numbers and stations of lymph nodes dissected, numbers experienced intraoperative transt (open thoracotomy / two to three-port thoracoscopic lobectomy switch), ambulation time, chest tube duration, numbers of complications, hospital stay after surgery were observed in both groups. Visual analog scale(VAS)was used to evaluate the severity of postoperative pain of patients on the 1st, 3rd and 7th day after operation, and the analgesic dosages used after operation were also recorded. The follow-up information were collected, and the incidence rates of local recurrence and distant metastasis were compared. The 3-year overall survival rate and progress free survival rate were also analyzed. 【Results】No significances were found between the two groups in operation duration, numbers and stations of lymph nodes dissected, incidence rates of intraoperative transit , and chest tube duration(P＞0.05). The ambulation time and hospital stay after surgery of the observation group were significantly shorter than those of the control group(P＜0.05). The complication rate of the observation group was 26.21%, which was lower than that of the control group(26.47%), but the difference had no statistical significance(P＞0.05). The VAS score of the observation group on the 1st day was lower than that of the control group with no significance(P＞0.05), while the scores on the 3rd and 7th day were significantly lower than those of the control groups(P＜0.05). The analgesic dosages used after operation of the observation group were significantly less than those of the control group(P＜0.05). No significance existed between the two groups in the incidence rates of local recurrence and distant metastasis(P＞0.05). The difference in 3-year overall survival rate, progress free survival rate and median survival time between the two groups were also not significance(P＞0.05).【Conclusion】Compared to the three-port thoracoscopic lobectomy with systematic lymph node dissection, the two-port thoracoscopic lobectomy with systematic lymph node dissection can efficiently dissected the cancer tissue, and the therapeutic effect is desirable.It can alleviated postoperative pain and promote the rehabilitation of patients.
2017, Vol. 34 
