Abstract：Objective To investigate the impact of axillary lymph node metastasis on the survival of elderly women with breast cancer. Methods The clinical and pathological data of 106 elderly patients with primary invasive breast cancer admitted to our hospital from October 2014 to October 2016 were retrospectively analyzed. The tumor size, estrogen receptor (ER) and progesterone receptor (PR) status, histological differentiation, positive number of lymph node metastasis, number of lymph node metastasis at level Ⅰ~Ⅱ, axillary lymph node metastasis and recurrence-free survival rate (RFS) were analyzed. ) Prognostic correlations such as overall survival rate (OS) were also discussed. Kaplan-Meier survival analysis was used to analyze the differences of RFS and OS between patients with simple axillary lymph node metastasis and those with extranodal axillary lymph node metastasis.Results Univariate analysis showed that the size of tumor, the number of positive lymph node metastasis and the number of lymph node metastasis at Ⅰ~Ⅱ level had significant effect on the extranodal metastasis of axillary lymph node (P<0.05). Cox multivariate analysis showed that the number of lymph node metastasis at the level of Ⅰ~Ⅱ had statistical significance. The size of tumor, the number of lymph node positive metastasis, the rate of lymph node metastasis and axillary lymph node metastasis were the risk factors of RFS,OS, the difference was statistically significant (P<0 05). The survival analysis of Kaplan-Meier showed that there was no significant difference between the two groups (P<0 05). In patients with axillary lymph node alone, RFS was 73.68% (42 / 57), OS, 91.22%(52/57). The RFS in patients with axillary lymph node metastasis with axillary lymph node extranodal metastasis was 32.65% (16 / 49), OS 44.80%( 22 / 49), which was lower than that in patients with simple axillary lymph node metastasis. Log-Rank test was performed on the patients with axillary lymph node metastasis and extranodal metastasis. The difference was statistically significant (P<0.05).Conclusion Tumor size, positive lymph node, number of lymph node metastasis, rate of lymph node metastasis and axillary lymph node metastasis can be used as risk factors of RFS,OS in elderly patients with breast cancer.
王旷, 李桂梅. 腋窝淋巴结结外转移对老年乳腺癌患者生存状况的影响[J]. 医学临床研究, 2019, 36(2): 303-305.
WANG Kuang, LI Gui-mei. Influence of Axillary Lymph Node Extranodal Metastasis on Survival status of Elderly Patients with Breast Cancer. JOURNAL OF CLINICAL RESEARCH, 2019, 36(2): 303-305.
2019, Vol. 36 
