Abstract：【Objective】To observe the expression levels of PR-A, PR-B and PR-M in uterine leiomyoma tissues and analyze their clinical significance. 【Methods】Patients with uterine leiomyoma who were treated in our hospital from March 2017 to May 2018 were selected as the observation objects. The expression levels of PR-A, PR-B and PR-M in uterine leiomyoma and normal tissues were observed. The expression levels of PR-A, PR-B and PR-M in patients with different characteristics of uterine leiomyoma were compared. The factors influencing the expression of PR-A, PR-B and PR-M in patients with uterine leiomyoma were analyzed. 【Results】The expressions of PR-A, PR-B and PR-M in uterine leiomyoma were 0.79±0.09, 0.93±0.10, 0.09±0.005, higher than those in normal tissues (P<0.001); the expressions of PR-A, PR-B and PR-M were higher in patients with uterine leiomyoma whose number of leiomyomas was more than 2 and the diameter of leiomyoma was more than 5 cm. The expressions of PR-A, PR-B and PR-M were higher in patients with uterine leiomyoma at different ages, reproductive history, hypertension and diabetes mellitus. The expression levels of PR-A, PR-B and PR-M protein in leiomyoma tissues of patients with uterine leiomyoma were not affected (P>0.05). Multivariate regression analysis showed that the diameter of leiomyoma and the number of leiomyomas were the influencing factors of the expression of PR-A, PR-B and PR-M protein in patients with uterine leiomyoma. 【Conclusion】The expression of PR-A, PR-B and PR-M in uterine leiomyoma is high, and is affected by the number of leiomyoma and the diameter of leiomyoma.
蒲丹, 张川利. PR-A、PR-B、PR-M在子宫肌瘤组织中的表达及其临床意义[J]. 医学临床研究, 2019, 36(5): 914-916.
PU Dan, ZHANG Chuan-li. Expression and Clinical Significance of PR-A, PR-B and PR-M Proteins in Uterine Leiomyoma. JOURNAL OF CLINICAL RESEARCH, 2019, 36(5): 914-916.
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2019, Vol. 36 
