Abstract：【Objective】To investigate th ors after surgical treatment.【Methods】The clinical data of 191 patients with posterior fossa tumors from January 2008 to January 2018 were retrospectively analyzed. 25 patients (13.09%) with intracranial infection after operation were monitored and recorded, including body temperature, C-reactive protein (CRP), peripheral blood leukocyte count (WBC), CSF examination results, serum procalcitonin (PCT), and the results of peak and first CSF examination, biochemical indicators, lumbar puncture time were compared.January 2018 were selected. Postoperative intracranial infection in 25 (13.09%)patients. The clinical symptoms and signs of patients with intracranial infection were monitored and recorded, including body temperature, C reactive protein, peripheral blood leukocyte count, CSF test results, serum procalcitonin monitoring. The peak time, the first CSF test results, biochemical indicators, lumbar puncture time were compared (continuous CSF examination of the highest number of nuclear cells in the time that is the peak number of CSF nucleated cells, if the first time the number of CSF patients with the highest nuclear cells, then according to the patient first time). The therapeutic effect and treatment time of the two groups were compared. The results of CSF culture were analyzed. 【Results】All the patients with intracranial infection had fever symptoms of varying degrees. The fever time after operation was (6.21±72) d, WBC was (14.32 ±4.78)×109/L , body temperature was (38.17±0.42)℃, CRP was (28.54±14.34) mg/L, PCT was (2.44±0.45) ng/mL. The above indexes were significantly increased [CRP<10 mg/L, WBC(4~10)×109/L, PCT<0.5 ng/mL was normal]. The infection control time was (15.58±4.89) days. The number of nucleated cells and protein content of CSF in peak period were significantly higher than those in the first time, and the chloride content in peak period was lower than that in the first time (P<0.05). CSF culture results showed that 5 cases were positive (20.00%). Four of them were gram-negative bacteria, including Streptococcus mitigatus, Staphylococcus hemolyticus, Moraxella Oslo, Acinetobacter baumannii complex, Escherichia coli and Pseudomonas sp. Two different strains of bacteria were cultured by CSF in one case, they were Streptococcus mitigatus (G+) and Escherichia coli (G-).【Conclusion】The early clinical characteristics of intracranial infection in patients with posterior cranial fossa tumors after surgical treatment are not specific. The CSF culture of patients has a low positive rate. After surgical treatment, patients suspected of intracranial infection should be examined by CSF many times. Anti-gram-negative drugs should be used empirically as soon as possible.
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2019, Vol. 36 
