Abstract：【Objective】To explore the pathogenic distribution with bloodstream infection and post-chemotherapy drug resistance in patients with leukemia. 【Methods】Retrospective analysis of the clinical data of 325 leukemia patients with blood stream infection after chemotherapy was conducted to investigate the distribution of pathogenic bacteria and drug resistance of blood stream infection. 【Results】Among the 350 pathogenic strains we checked, 100 were Gram-positive bacteria (G+)( 28.57%), 245 were Gram-negative bacteria (G-)(70.0%)and 5 were fungi(1.43%). The isolated pathogens were mainly Klebsiella pneumoniae (21.14%), Escherichia coli (20.57%), coagulase-negative staphylococci (17.71%), Pseudomonas aeruginosa (14.29%) and golden yellow Staphylococcus (4.86%). Escherichia coli and Klebsiella pneumoniae isolated from Gram-negative bacteria (G-), which produced the extended-spectrum β-lactamase, were more resistant to antibiotics than non-ESBLs strains. Enterobacteriaceae (intestinal bacilli) were less resistant to carbapenem drugs, tigecycline, and piperacillin (less than 14%). The resistance rates of Acinetobacter baumannii to cefotaxime and cefixime were both 7.0%, and their resistance rates to cefoxitin and cefazolin were both higher than 50.0%. In addition, they were sensitive to tigecycline. The resistance rate of Pseudomonas aeruginosa to various antimicrobial agents was below 12.0%. We did not detect any resistance to linezolid, vancomycin and tigecycline in Gram-positive bacteria (G+). 【Conclusion】 There are a variety of types of pathogenic bloodstream infections in leukemia patients after chemotherapy. Gram-negative bacteria (G-) are the main stains, which have more serious drug resistance. Linezolid, vancomycin and tigecycline can be applied to the treatment of Gram-positive bacteria (G+) bloodstream infections.
余广琼, 刘航, 何林林, 张利沙, 程忠颖, 黄文静. 白血病患者化疗后血流感染致病菌和耐药性分析[J]. 医学临床研究, 2019, 36(4): 678-680.
YU Guang-qiong, LIU Hang, HE Lin-lin, et al. Pathogen and Drug Resistance of Leukemia Patients after Chemotherapy in Hospital. JOURNAL OF CLINICAL RESEARCH, 2019, 36(4): 678-680.
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2019, Vol. 36 
