Abstract：【Objective】 To detect the serum level of nesfatin-1 in patients with stable chronic obstructive pulmonary disease (COPD) and explore its relationship with nutritional indicators and lung function. 【Methods】 A total of 100 patients with stable COPD and 100 healthy volunteers were selected as COPD group and healthy control group, respectively. Serum nesfatin-1 levels were detected by enzyme-linked immunosorbent assay (ELISA), and the nutritional indicators and lung function were detected and compared as well. The nutritional indicators included hemoglobin (Hb) and serum albumin (ALB). The lung function index included percentage of forced expiratory volume in the first second (FEV1),FEV1/FVC. Pearson correlation analysis was used to determine the correlation between serum nesfatin-1 level and nutritional status and lung function in patients with stable COPD. 【Results】 The serum nesfatin-1 level in the COPD group was higher than that in the healthy control group. The Hb, ALB nutritional, FEV1 and FEV1/FVC were significantly lower the healthy group. The differences were statistically significant (P<0.05). The serum nesfatin-1 levels were negatively correlated with Hb, ALB, FEV1, and FEV1/FVC in the COPD group (r=-0.608, -0.522, -0.529, -0.478,P<0.05). 【Conclusion】 Serum nesfatin-1 levels may be a potential biomarker for nutritional assessment and pulmonary function grading in patients with COPD.
2018, Vol. 35 
