血清Cys-C、HCY及BTP与妊娠期高血压患者病情程度的相关性研究

doi:10.3969/j.issn.1671-7171.2018.08.021

摘要
图/表
参考文献(20)
相关文章 (15)

全文: PDF (0 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要【目的】探讨血清胱抑素-C(Cys-C)、同型半胱氨酸(HCY)及β-痕迹蛋白(BTP)与妊娠期高血压疾病患者病情程度的相关性。【方法】选择2013年7月至2017年6月在本院诊治的82例妊娠期高血压疾病患者作为观察组(A组),按照不同的病情程度分为三个亚组:妊娠期高血压组(29例,A1组)、子痫前期轻度组(28例,A2组)和子痫前期重度组(25例,A3组)。以同期在本院住院的健康妊娠妇女82例为对照组(B组),分别检测以上各组受试对象血清Cys-C、HCY及BTP水平,分析Cys-C、HCY及BTP水平与患者病情程度相关性。【结果】 A组血清Cys-C、HCY及BTP的水平均高于B组相对应的血清水平(P＜0.05),A3组血清Cys-C、HCY及BTP的水平高于A2组和A1组相对应的血清水平(P＜0.05),A2组血清Cys-C、HCY及BTP的水平高于A1组相对应的血清水平(P＜0.05);血清Cys-C、HCY 及BTP水平与妊娠期高血压疾病患病程呈现明显正相关关系(P＜0.05)。【结论】血清Cys-C、HCY及BTP水平与妊娠期高血压疾病病情程度呈明显正相关,并且随着病情程度的加重而升高明显,检测血清中三项指标有助于指导妊娠期高血压疾病临床诊治。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	孙修丽
	陈思
	胡猛

关键词 ：高血压, 妊娠性/病理生理学, 抑素类, 半胱氨酸, 蛋白质类

Abstract：【Objective】 To explore the correlation of serum cystatin-C (Cys-C), homocysteine (HCY) and beta-trace protein (BTP) levels with the severity in patients with pregnancy-induced hypertension. 【Methods】 A total of 82 patients with diagnosis of pregnancy-induced hypertension disease from July 2013 to June 2017 in our hospital were selected as the observation group (group A). According to the severity of the disease, patients were divided into three subgroups: 29 cases of gestational hypertension group (A1), 28 cases of mild preeclampsia group (A2), and 25 cases of severe preeclampsia group (A3). In the same period, 82 healthy pregnant women admitted in our hospital were enrolled as the control group (group B). The levels of serum Cys-C, HCY and BTP, were detected in patients of all groups. The severity of pregnancy-induced hypertension in correlation with the levels of Cys-C, HCY and BTP were analyzed . 【Results】 The levels of serum Cys-C, HCY and BTP in the observation group (A) were higher than those of control group (B) (P<0.05). The levels of serum Cys-C, HCY and BTP in the severe preeclampsia group (A3) were higher than those of mild preeclampsia group (A2) and gestational hypertension group (A1). The levels of group A2 were higher than those of group A1 (P<0.05). Furthermore, the serum levels of Cys-C, HCY and BTP were significantly positively correlated with the severity of pregnancy-induced hypertension. 【Conclusion】 The levels of serum Cys-C, HCY and BTP positively reflected the severity of pregnancy-induced hypertension. Detection of these three serum indicators can help the clinical diagnosis and treatment of pregnancy-induced hypertension .

Key words： Hypertension Pregnancy-Induced/PP Chalones Cysteine

收稿日期: 2018-05-21

PACS:

R714.246

引用本文:

孙修丽, 陈思, 胡猛. 血清Cys-C、HCY及BTP与妊娠期高血压患者病情程度的相关性研究[J]. 医学临床研究, 2018, 35(8): 1520-1523.
SUNXiu-li, CHENSi, HUMeng. Correlation of Serum Cys-C, HCY and BTP Levels with Severity in Patients with Pregnancy-Induced Hypertension. JOURNAL OF CLINICAL RESEARCH, 2018, 35(8): 1520-1523.

链接本文:

http://www.jcr.net.cn/CN/10.3969/j.issn.1671-7171.2018.08.021 或 http://www.jcr.net.cn/CN/Y2018/V35/I8/1520

[1] Mounier-Vehier C, Madika A L, Boudghène-Stambouli F, et al. Hypertension in pregnancy and future maternal health[J]. Presse Med, 2016,45(7-8 Pt1):659-666.
[2] 魏继文, 吴萍. 妊娠期高血压疾病相关影响因素分析[J]. 重庆医学, 2016,45(22):3078-3080.
[3] Duan B, Zhang L, Ding X, et al. Serum beta-trace protein as a novel predictor of pregnancy-induced hypertension[J]. J Clin Hypertens, 2016,18(10):1022-1026.
[4] 韦月颜, 孙明霞, 王秀妹. 血清Cys-C与HCY在妊娠高血压综合征患者的表达及临床意义[J]. 中国地方病防治杂志, 2017(05):499-502.
[5] 刘成花, 冯彩滑, 付彩霞, 等. 血清胱抑素C、同型半胱氨酸及β2-微球蛋白评估妊娠期高血压疾病患者肾损伤的临床价值[J]. 中国妇幼保健, 2017,32(21):5247-5249.
[6] Ortuno-Anderiz F, Cabello-Clotet N, Vidart-Simon N, et al. Cystatin C as an early marker of acute kidney injury in septic shock[J]. Rev Clin Esp, 2015,215(2):83-90.
[7] PhD Z Y M, PhD C W M, Qunzi Zhang M D, et al. Prevalence of homocysteine-related hypertension in patients with chronic kidney disease[J]. J Clin Hypertens, 2017,19(2): 151-160
[8] Yang F, Qi X, Gao Z, et al. Homocysteine injures vascular endothelial cells by inhibiting mitochondrial activity.
[J]. Experimental & Therapeutic Medicine, 2016, 12(4):2247-2252.
[9] Miyata S, Inoue J, Shimizu M, et al. Allylisothiocyanate suppresses the proteolytic activation of sterol regulatory element-binding proteins and de novo fatty acid and cholesterol synthesis.
[J]. Biosci Biotechnol Biochem, 2016,80(5):1-6.
[10] Fauvel J P. Hypertension during pregnancy: Epidemiology, definition[J]. Presse Med, 2016,45(7-8 Pt 1):618-621.
[11] 尹智敏, 李荣, 柳宇, 等. 胱抑素C、同型半胱氨酸检测评估妊娠期高血压综合征患者肾损伤的价值[J]. 江苏医药, 2016(18):2033-2035.
[12] 黄成. 探讨联合检测血清Cys-C 和 RBP 对慢性肾脏病早期肾功能诊断的意义[J]. 中国实验诊断学, 2015(10):1676-1679.
[13] Bacci M R, Chehter E Z, Azzalis L A, et al. Serum NGAL and cystatin C comparison with urinary albumin-to-creatinine ratio and inflammatory biomarkers as early predictors of renal dysfunction in patients with type 2 diabetes[J]. Kidney Int Rep, 2017,2(2):152-158.
[14] 吕磊, 许燕丽, 武孟香, 等. 血清胱抑素C对妊娠期高血压疾病孕妇肾功能损害的诊断价值[J]. 中国妇产科临床杂志, 2015(4):353-354.
[15] 朱沙沙. 妊高征患者监测血清Hcy、叶酸、维生素B_(12)水平的价值[J]. 心血管康复医学杂志, 2016(03):315-317.
[16] 陈志晓, 黎莉, 陈金玲, 等. 血清Cys-C、Hcy、Scr和 Urea 联合检测在妊娠高血压综合征肾功能损伤诊断中的价值[J]. 山东医药, 2015(28):63-64.
[17] 姜帆, 罗徳梅. 血清Cys-C、Hcy、NAG及mALB水平检测诊断妊娠期高血压疾病早期肾损害的价值[J]. 中国妇幼保健, 2017,32(15):3437-3439.
[18] Mouelhi A E. A BTP-based family of variable elimination rules for binary CSPs: AAAI, 2017[C].
[19] Wang L, Yuan G, Chen G, et al. Relationship between serum cystatin C level and SYNTAX score in patients with non-ST segment elevation acute coronary syndrome[J]. J Electrocardiol Circ, 2016,02(541):2.
[20] 段彼得. 血清标志物β-痕迹蛋白(BTP)在预测妊娠高血压疾病的应用研究[D]. 山东大学, 2017.