Abstract：【Objective】To investigate the clinical value of combined detection of serum human epididymal protein 4 (HE4), ovarian cancer carbohydrate antigen 125 (CA125), B7-H4, B7-H6 and peripheral blood Foxp3+Treg in ovarian cancer Value. 【Methods】From February 2012 to February 2017, 105 patients with ovarian cancer diagnosed by pathology in Obstetrics and Gynecology of the Second People's Hospital of Hengshui City were selected as observation group and 105 as benign ovarian tumors as control group. All patients underwent HE4, CA125, B7-H4, B7-H6 detection and peripheral blood Foxp3+ Treg levels. 【Results】The serum levels of HE4, CA125, B7-H4, B7-H6 and peripheral blood Foxp3+ Treg in the observation group were significantly higher than those in the control group (P<0.05). The sensitivity, specificity, positive predictive value and negative predictive value of combined detection were better than single detection results of serum HE4, CA125, B7-H4, B7-H6 and peripheral blood Foxp3+ Treg, the difference was statistically significant (P<0.05) . 【Conclusion】The combined detection of serum HE4, CA125, B7-H4, B7-H6 a nd peripheral blood Foxp3+ Treg has higher sensitivity, specificity, positive predictive value and negative predictive value, which can help to improve the diagnosis rate of ovarian cancer.
2018, Vol. 35 
