Abstract： Objective To investigate the application value of neoadjuvant chemotherapy in sequential treatment of stage Ⅲ esophageal cancer. Methods One hundred patients with stage Ⅲ esophageal cancer were divided into radical radiotherapy group (control group,n=42) and the neoadjuvant sequential chemotherapy group (observation group) according to the treatment methods. The tumor control, treatment effect, safety and quality of life were compared between the two groups. Results The overall remission rate, tumor control rate followed up for 1~3 years, and follow-up survival rate of the observation group were not significantly different compared with those of the control group (P>0.05);Ⅰ~Ⅳ gastrointestinal reaction and the incidence of radiation esophagitis atⅠ~Ⅱgrade of the observation group were lower than those of the control group (P<0.05); There was no significant difference in quality of life between the two groups before treatment (P>0.05). The quality of life scores of the two groups were increased at different times (P<0.05), the quality of life scores of 1~2 year - followed-up were higher than those in the control group (P<0.05). Conclusion The efficacy of neoadjuvant chemotherapy sequential treatment and concurrent radiotherapy /chemotherapy is similar in the treatment of patients with esophageal cancer , but neoadjuvant sequential chemoradiotherapy regimen is safe and can improve the long-term quality of life.
2017, Vol. 34 
