摘要【目的】评价复方苦参注射液联合放化疗治疗宫颈癌的疗效。【方法】收集2015年6月至2017年1月在本院接受治疗的宫颈癌患者105例,根据治疗方案分为单用组和联合组。单用组52例,给予同步放化疗;联合组53例,在对照组基础上加用复方苦参注射液治疗。于治疗前、治疗3个疗程后,比较两组患者T淋巴细胞亚群、自然杀伤细胞(NK)及血清肿瘤抗原[胰岛素样生长因子-2(IGF-2)、鳞状细胞癌相关抗原(SCC)、细胞角蛋白19片断抗原(CYFRA21-1)]水平变化,并评价两组治疗疗效及安全性。【结果】联合组治疗总有效率52.83%(28/53),显著高于单用组的32.69%(17/52);不良反应发生率为47.17%(25/53),显著低于单用组75.00%(39/52),差异有统计学意义( P <0.05);治疗后联合组CD3+、CD4+、CD4+/CD8+、NK水平均较单用组高,CD8+水平较单用组低,其差异均有统计学意义( P <0.05);治疗后联合组IGF-2、SCC、CYFRA21-1水平均较单用组低,其差异有统计学意义( P <0.05)。【结论】宫颈癌患者采用复方苦参注射液联合放化疗治疗,疗效确切,能增强细胞免疫功能,降低肿瘤抗原水平和不良反应发生率,值得临床推广应用。
Abstract：【Objective】To evaluate the effect of compound Kushen injection combined with radiotherapy and chemotherapy on cervical cancer. 【Methods】The clinical data of 105 patients with cervical cancer who were treated in our hospital from June 2015 to January 2017 were collected. According to different treatment regimens, patients were divided into the single-use group and the combined group. The single-use group consisted of 52 cases who were given concurrent radiotherapy and chemotherapy, while the combined group of 53 cases received the compound Kushen injection plus chemoradiotherapy. T lymphocyte subsets, natural killer cells (NK) and serum tumor antigens [insulin-like growth factor-2 (IGF-2), squamous cell carcinoma-associated antigens were observed before and after treatment for 3 courses. SCC and cytokeratin 19 fragment antigen (CYFRA21-1)] were measured before treatment and after 3 courses of treatment. The therapeutic efficacy and safety between the two groups were evaluated and compared. 【Results】The total effective rate of the combined group was 52.83% (28/53), which was significantly higher than that of the single-use group, which was 32.69% (17/52). The incidence of adverse reactions was 47.17% (25/53) in the combined group, which was lower than in the single-use group, which was 75.00% (39/52). The difference was statistically significant ( P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+ and NK in the combined group were higher than those in the single-use group, and the differences were statistically significant ( P < 0.05). The CD8+ level in the combined group was lower than that in the single-use group ( P < 0.05). After treatment, the levels of IGF-2, SCC and CYFRA21-1 in the combined group were lower than those in the single-use group ( P < 0.05). 【Conclusion】The application of Kushen injection combined with radiotherapy and chemotherapy in patients with cervical cancer is effective in promoting the enhancement of cellular immune function, reducing the level of tumor antigen and reducing the occurrence of adverse reaction.
蔡涛, 孙兰珍, 王婷, 王健. 复方苦参注射液联合放化疗治疗宫颈癌的疗效观察[J]. 医学临床研究, 2018, 35(7): 1262-1264.
CAI Tao, SUN Lan-Zheng, WANG Ting, et al. Effect of Compound Kushen Injection Combined with Radiotherapy and Chemotherapy on Cervical Cancer. JOURNAL OF CLINICAL RESEARCH, 2018, 35(7): 1262-1264.
2018, Vol. 35 
