Abstract：【Objective】 To investigate the effect of cinobufacini capsules combined with hepatic arterial infusion chemoembolization in patients with liver cancer. 【Methods】Sixty-eight patients with hepatocellular carcinoma treated in our hospital were randomly divided into group A and group B, 34 cases in each. On the basis of TACE, the Group A was treated with the cinobufacini capsules, and the Group B underwent hepatic artery TACE only. The changes of plasma fibrinogen (FIB), tumor markers, clinical efficacy and quality of life were compared between the two groups before and after treatment.【Results】 There was no significant difference in FIB content between the two groups before treatment (P>0.05), and no significant difference existed in FIB content in the Group A before and after treatment (P>0.05) ; The FIB content in the group B was significantly higher than that before treatment, and was even significantly higher than that in the Group A (mean P<0.05). After treatment, the Cytokeratin 19 fragments, CEA, NSE concentrations of the two groups were significantly lower than those before treatment, and the difference was significant (P<0.05). It showed no significant difference between the three indexes of the Group A and the Group B after treatment (P>0.05).The disease control rate of the Group A was 77.5% (26/34), which was significantly higher than that of the Group B 67.6% (23/34); The incidence of pain and fatigue in the Group A was significantly lower than that in the Group B (P<0.05).【Conclusion】Cinobufacini capsules combined with TACE can improve the hypercoagulable state of blood in patients, which is beneficial for the treatment of cancer, improve the control rate of disease and improve the life quality of patients.
叶璐;杨莉;母丹;王敏;付波;. 华蟾素胶囊联合肝动脉灌注化疗栓塞治疗肝癌患者的疗效[J]. 医学临床研究, 2017, 34(4): 688-690,692.
YE Lu, YANG Li, MU Dan,et al. Effect of Huachansu (Cinobufacini)Capsule Combined with Hepatic Arterial Infusion Chemoembolization in Patients with Liver Cancer. JOURNAL OF CLINICAL RESEARCH, 2017, 34(4): 688-690,692.
2017, Vol. 34 
