Effect of Injection of Tirofiban through Thrombus Aspiration Catheter on TIMI Blood Flow Grad and Cardiac Function in Acute STEMI Patients Undergoing Emergency PCI
ZHAO Na
Deparment of CCU, Shangcai Caizhou Hospital, Zhumadian Henan 463800
Abstract：【Objective】 To investigate the effects of tirofiban injected via thrombus aspiration catheter on thrombolysis in myocardial infarction(TIMI) flow grade and cardiac function in patients with acute ST-segment elevation myocardial infarction(STEMI) undergoing primary percutaneous coronary intervention(PCI).【Methods】 A total of 82 patients with acute STEMI admitted to our hospital from January 2022 to January 2024 were selected. All patients underwent emergency PCI and were divided into an observation group and a control group based on different treatment methods, with 41 groups in each group. All patients underwent thrombus aspiration first. The control group underwent PCI surgery directly, while the observation group underwent PCI surgery after injection of tirofiban through the aspiration catheter. Laboratory indicators [creatine kinase isoenzyme(CK-MB), C-reactive protein(CRP)], cardiac function indicators [left ventricular ejection fraction(LVEF), left ventricular end diastolic diameter(LVEDD)], and myocardial infarction thrombolysis test(TIMI) blood flow grading before PCI procedure and at 7 days after PCI surgery were compared between the two groups. The incidence of major adverse cardiovascular events(MACE) within 6 months after surgery were compared between two groups of patients.【Results】 Seven days after surgery, the serum CK-MB and CRP levels in both groups were lower than before surgery, and the levels of CK-MB and CRP in the observation group was lower than those in the control group, with a statistically significant difference(P<0.05). After surgery, both groups of patients had higher LVEF and lower LVEDD than before surgery, while patients in the observation group had higher LVEF and lower LVEDD than those in the control group, with statistical significance(P<0.05). The proportion of patients with TIMI blood flow grade 3 in the observation group was significantly higher than that in the control group, and the difference was statistically significant(P<0.05). After a 6-month follow-up, the incidence of MACE in the observation group was 9.76%(4/41), which was lower than 31.71%(13/41)in the control group, and the difference was statistically significant(P<0.05).【Conclusion】 Injection of tirofiban through thrombus aspiration catheter can effectively inhibit the inflammatory response of acute STEMI patients undergoing emergency PCI, reduce the levels of myocardial injury markers, restore blood flow perfusion to ischemic myocardial tissue, improve patient cardiac function, and reduce the incidence of MACE.
赵娜. 经血栓抽吸导管注射替罗非班对行急诊PCI急性STEMI患者的TIMI血流分级及心功能的影响[J]. 医学临床研究, 2025, 42(9): 1580-1582.
ZHAO Na. Effect of Injection of Tirofiban through Thrombus Aspiration Catheter on TIMI Blood Flow Grad and Cardiac Function in Acute STEMI Patients Undergoing Emergency PCI. JOURNAL OF CLINICAL RESEARCH, 2025, 42(9): 1580-1582.
2025, Vol. 42 
