Abstract：【Objective】 To explore the application value of intravenous thrombolysis in patients with non-disabling mild acute ischemic stroke.【Methods】 A total of 61 patients with non-disabling mild acute ischemic stroke were divided into an observation group(intravenous thrombolysis combined with dual antiplatelet therapy, n=33) and a control group(dual antiplatelet therapy, n=28) according to different treatment methods. The National Institutes of Health Stroke Scale(NIHSS) scores at 24 h, 72 h, and 7 days after treatment were compared between the two groups. At 3 months after treatment, the modified Rankin Scale(mRS) score, Extended Barthel Index(EBI) score, hematological indices [interleukin-6(IL-6), high-sensitivity C-reactive protein(hs-CRP), and lipoprotein-associated phospholipase A2(Lp-PLA2)], as well as the incidences of symptomatic intracranial hemorrhage, neurological deterioration, and stroke recurrence, were evaluated.【Results】 The NIHSS scores at 24 h, 72 h, and 7 days after treatment in the observation group were significantly lower than those in the control group(P<0.05). After 3 months of treatment, the mRS score, IL-6, and hs-CRP levels in the observation group were lower than those in the control group, while the EBI score and Lp-PLA2 levels were higher than those in the control group(all P<0.05). There were no statistically significant differences in the total incidence of symptomatic intracranial hemorrhage, neurological deterioration, or stroke recurrence between the two groups within 3 months(P>0.05).【Conclusion】 Intravenous thrombolysis can significantly improve early neurological function, promote long-term functional recovery, and reduce systemic inflammatory responses in patients with non-disabling mild acute ischemic stroke, with good safety.
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2025, Vol. 42 
