Abstract：【Objective】 To investigate the anesthetic effects of ultrasound-guided lumbosacral plexus nerve block(PNS) combined with propofol in patients undergoing lower limb orthopedic surgery, and its influence on serum level of neurospecific protein S-100β.【Methods】 Ninety patients scheduled for lower limb orthopedic surgery were randomly divided into two groups:the observation group(n=45), which received ultrasound-guided PNS combined with propofol, and the control group(n=45), which received combined spinal-epidural anesthesia. Anesthetic effects, postoperative adverse reactions, and serum S-100β protein levels at different time points were compared between the two groups.【Results】 At 3, 6, 12, and 24 hours postoperatively, the visual analogue scale(VAS) pain scores in the observation group were significantly lower than those in the control group(P<0.05). The onset time of sensory nerve block was shorter in the observation group(P<0.05), while the duration of both sensory and motor nerve block in the observation group was longer than that in the control group(P<0.01). Mean arterial pressure at 10 minutes after anesthesia and 10 minutes after surgery were higher in the observation group(P<0.05). The incidence of adverse reactions was lower in the observation group compared to the control group. Serum S-100β protein levels at 30 minutes during surgery, and at 1 and 6 hours postoperatively, were significantly lower in the observation group(P<0.01).【Conclusion】 Ultrasound-guided PNS combined with propofol provides effective anesthesia for lower limb orthopedic surgery, with fewer adverse reactions and neurological complications. It is therefore worthy of clinical promotion.
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2025, Vol. 42 
