IL-6/STAT3信号通路相关因子对下肢动脉硬化闭塞症介入治疗后再狭窄的预测价值杨帆

doi:10.3969/j.issn.1671-7171.2025.08.013

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摘要【目的】探讨白细胞介素-6(IL-6)/信号传导及转录激活蛋白3(STAT3)通路相关因子对下肢动脉硬化闭塞症(LASO)患者介入治疗后再狭窄的预测价值。【方法】选择2020年1月至2023年1月本院收治的125例LASO患者,根据患者预后情况将患者分为预后不良组(病变段血管再狭窄＞50%,n=41)和预后良好组(n=84)。比较患者入院后血清中IL-6、IL-6 受体(IL-6R)、Janus蛋白酪氨酸激酶2(JAK2)、STAT3、血管内皮生长因子(VEGF)、一氧化氮(NO)水平,采用Logistic多因素分析影响LASO患者介入治疗预后的相关因素,采用受试者工作特征(ROC)曲线评估IL-6/STAT3信号通路相关因子预测患者预后的价值。【结果】预后不良组患者血清总胆固醇(TC)水平高于预后良好组,踝肱指数低于预后良好组,差异有统计学意义(P<0.05)。预后不良组IL-6、IL-6R、JAK2、STAT3和VEGF水平均高于预后良好组,NO水平低于预后良好组(均P<0.05)。Logistic多因素回归分析显示,IL-6、IL-6R、JAK2、STAT3、VEGF水平高,NO水平低,是LASO患者介入术后发生再狭窄的危险因素(P<0.05)。ROC曲线显示,IL-6、IL-6R、JAK2、STAT3联合检测对下肢动脉硬化闭塞症介入治疗患者的预后情况有较高的诊断效能。【结论】IL-6/STAT3信号通路涉及的相关因子与LASO患者介入治疗的预后密切相关,IL-6、IL-6R、JAK2、STAT3水平较高的患者发生再狭窄的风险更高。

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	杨帆
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关键词 ：白细胞介素6, STAT3转录因子, 闭塞性动脉硬化, 下肢, 血管内操作, 缩窄,病理性

Abstract：【Objective】To investigate the predictive value of interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway-related factors for restenosis after endovascular therapy in patients with lower extremity arteriosclerosis obliterans (LEASO). 【Methods】A total of 125 LEASO patients admitted to our hospital between January 2020 and January 2023 were enrolled. Patients were divided into poor-prognosis group (vascular restenosis >50%, n=41) and good-prognosis group (n=84) based on follow-up outcomes. Serum levels of IL-6, IL-6 receptor (IL-6R), Janus kinase 2 (JAK2), STAT3, vascular endothelial growth factor (VEGF), and nitric oxide (NO) were measured. Logistic regression analysis was used to identify risk factors for restenosis. Receiver operating characteristic (ROC) curves evaluated the predictive efficiency of the IL-6/STAT3 pathway. 【Results】 Poor-prognosis patients showed higher total cholesterol (TC) levels and lower ankle-brachial index (ABI) compared to good-prognosis patients (all P<0.05). Serum IL-6, IL-6R, JAK2, STAT3, and VEGF levels were significantly elevated, while NO levels were decreased in the poor-prognosis group (mean P<0.05). Multivariate analysis revealed high IL-6, IL-6R, JAK2, STAT3, VEGF levels and low NO levels as independent risk factors for restenosis (P<0.05). The ROC curve showed that the combined detection of IL-6, IL-6R, JAK2, and STAT3 had high diagnostic efficacy for the prognosis of patients with lower extremity arteriosclerosis obliterans who underwent interventional therapy.【Conclusion】IL-6/STAT3 pathway-related factors are closely associated with restenosis risk after endovascular therapy in LEASO patients. Elevated IL-6, IL-6R, JAK2, and STAT3 levels indicate higher restenosis probability.

Key words： Interleukin-6 STAT3 Transcription Factor Arteriosclerosis Obliterans Lower Extremity Endovascular Procedures Constriction, Pathologic

收稿日期: 2025-02-19

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引用本文:

杨帆, 张雨, 臧升. IL-6/STAT3信号通路相关因子对下肢动脉硬化闭塞症介入治疗后再狭窄的预测价值杨帆[J]. 医学临床研究, 2025, 42(8): 1339-1342.
YANG Fan, ZHANG Yu, ZANG Sheng. Predictive Value of IL-6/STAT3 Signaling Pathway-Related Factors for Restenosis after Endovascular Therapy in Lower Extremity Arteriosclerosis Obliterans. JOURNAL OF CLINICAL RESEARCH, 2025, 42(8): 1339-1342.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.08.013 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I8/1339

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