Abstract：【Objective】To investigate the relationship between fibrinogen to prealbumin ratio(FPR), hemoglobin to red blood cell distribution width ratio(HRR) and prognosis of colorectal cancer patients. 【Methods】A total of 92 patients with colorectal cancer who underwent surgery were followed up for 3 years. According to the prognosis, they were divided into good prognosis group(no recurrence, metastasis or death) and poor prognosis group(recurrence, metastasis or death). The clinical data, FPR and HRR levels of the two groups were compared, and the factors affecting the prognosis of the patients were analyzed; Receiver operating characteristic(ROC) curve was used to analyze the predictive efficacy of FPR and HRR levels on the prognosis of patients. 【Results】 The incidence of poor prognosis in colorectal cancer patients within 3 years after operation was 22.83%(21/92). The FPR level in the poor prognosis group was higher than that in the good prognosis group, and the HRR level was lower than that in the good prognosis group(P<0.05). ROC curve showed that the sensitivity of FPR, HRR and their combination to predict the prognosis of patients were 76.20%, 57.10% and 90.50%, respectively, and the specificity was 77.50%, 69.00% and 88.70%, respectively. The area under the curve(AUC) was 0.804, 0.722 and 0.899, respectively. The proportion of poorly differentiated and TNM stage Ⅲa in the poor prognosis group was higher than that in the good prognosis group(P<0.05); There was no significant difference in gender, age, maximum diameter of tumor, tumor location, pathological type between the two groups(P>0.05). Cox multivariate analysis showed that TNM stage Ⅲa and FPR were risk factors for the prognosis of patients, while HRR was a protective factor for the prognosis of patients(P<0.05). The survival curve of patients with high FPR level was significantly different from that of patients with low FPR level(P<0.05). The survival curve of patients with low HRR level was significantly different from that of patients with high HRR level(P<0.05). 【Conclusion】The detection of FPR and HRR levels in patients with colorectal cancer can be used to predict the prognosis of patients, and the combined predictive value of the two is better.
何捷. 纤维蛋白原与前白蛋白比值、血红蛋白与红细胞分布宽度比与结直肠癌患者预后的关系[J]. 医学临床研究, 2024, 41(3): 356-359.
HE Jie. Relationship between Fibrinogen to Prealbumin Ratio, Hemoglobin to Red Blood Cell Distribution Width Ratio and Prognosis of Colorectal Cancer Patients. JOURNAL OF CLINICAL RESEARCH, 2024, 41(3): 356-359.
[1] VAN 'T ERVE I, MEDINA J E, LEAL A, et al. Metastatic colorectal cancer treatment response evaluation by Ultra-Deep sequencing of Cell-Free DNA and matched white blood cells[J].Clin Cancer Res,2023,29(5):899-909. [2] DAZIO G, EPISTOLIO S, FRATTINI M, et al. Recent and future strategies to overcome resistance to targeted therapies and immunotherapies in metastatic colorectal cancer[J].J Clin Med,2022,11(24):7523. [3] 吴永力, 方汉刚, 陈静, 等. 术前外周血微小RNA-21、血管内皮生长因子、糖类抗原19-9水平与结直肠癌病人临床分期和术后复发转移的关系[J].临床外科杂志, 2022,30(8):771-774. [4] LU L, LIU Y J, ZHANG G T, et al. The circRNA expression profile of colorectal inflammatory cancer transformation revealed potential predictive biomarkers[J].Aging(Albany NY),2022,14(22):9280-9299. [5] 马晨俊, 赵嘉闻, 黎承杨, 等. 基于决策曲线探讨术前纤维蛋白原与前白蛋白比值在肾透明细胞癌预后中的作用[J].中华实验外科杂志, 2022,39(6):1033-1037. [6] ZHAO W C, SHI M X, ZHANG J. Preoperative hemoglobin-to-red cell distribution width ratio as a prognostic factor in pulmonary large cell neuroendocrine carcinoma: a retrospective cohort study[J].Ann Transl Med,2022,10(2):42. [7] 中华人民共和国卫生和计划生育委员会医政医管局, 中华医学会肿瘤学分会. 结直肠癌诊疗规范(2015年版)[J].中华外科杂志, 2015,53(12):881-894. [8] 魏曼莉, 董云生, 魏金鑫, 等. 结直肠癌根治术前患者主观整体营养状况评分与近远期预后的相关性分析[J].肿瘤综合治疗电子杂志, 2023,9(3):115-119. [9] CERTO M, TSAI C, PUCINO V, et al. Lactate modulation of immune responses in inflammatory versus tumour microenvironments[J].Nat Rev Immunol,2021,21(3):151-161. [10] WU R Y, WANG L J, YIN R, et al. Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory-driven colon cancer[J].Mol Carcinog,2020,59(2):227-236. [11] 钱香, 王宏, 任真, 等. NLR与FIB和CEA及CA19-9在结直肠癌中的应用价值[J].中华预防医学杂志, 2021,55(4):499-505. [12] DING P, ZHENG C, CAO G, et al. Combination of preoperative plasma fibrinogen and AJCC staging improves the accuracy of survival prediction for patients with stage Ⅰ-Ⅱ gastric cancer after curative gastrectomy[J].Cancer Med,2019,8(6):2919-2929. [13] 季云, 李学勇, 高怡, 等. 纤维蛋白原与前白蛋白比值在结直肠癌预后预测中的作用[J].现代消化及介入诊疗, 2022,27(4):489-493. [14] 时慧, 赵邵林, 王加平. 血红蛋白与红细胞分布宽度比值对胃癌患者预后的预测价值[J].国际检验医学杂志, 2022,43(19):2421-2425. [15] ZHANG Z, LI Y, YAN X, et al. Pretreatment lactate dehydrogenase may predict outcome of advanced non small-cell lung cancer patients treated with immune checkpoint inhibitors: a meta-analysis[J].Cancer Med,2019,8(4):1467-1473. [16] 王畅, 房咏, 周洁, 等. 放疗前血红蛋白与红细胞分布宽度比值对Ⅲ、Ⅳ期非小细胞肺癌患者预后价值研究[J].临床军医杂志, 2022,50(3):242-245. [17] 方兴中, 杨建美, 梁海燕. 外周血炎症细胞比值对Ⅱ、Ⅲ期可切除直肠癌术后同步放化疗患者急性不良反应和预后的影响[J].中国现代医学杂志, 2022,32(8):85-91. [18] JUNG H, RYOO S, LIM H, et al. Tumor size>5 cm and Harvested LNs<12 are the risk factors for recurrence in stage Ⅰ colon and rectal cancer after radical resection[J].Cancers,2021,13(21):5294.
2024, Vol. 41 
