Abstract：【Objective】 To explore the clinical efficacy of Wushe Rongpi decoction in maintenance hemodialysis (MHD) patients with skin itching and its impact on their immune function. 【Methods】 A total of 100 patients with MHD accompanied by skin itching admitted to our hospital were randomly divided into an observation group and a control group, with 50 cases in each group. The control group received routine clinical treatment, while the observation group received Wushe Rongpi decoction. The clinical efficacy and incidence of adverse reactions were compared between the two groups after treatment. The TCM symptom score, immune function indicators, and serum levels of interleukin-2 (IL-2), interleukin-6 (IL-6), and tumor necrosis factor-α(TNF-α) were compared before and after treatment. 【Results】 The total effective rate of patients in the observation group was 92.00%, which was higher than 78.00% in the control group (P<0.05); The scores of skin itching, dark red rash, and increased erythema in the observation group after treatment were lower than those before treatment and in the control group after treatment (P<0.05); After treatment, the levels of CD3+ and CD4+ in the observation group were significantly higher than those before treatment and the control group, while the levels of CD8+ were significantly lower than those before treatment and the control group (P<0.05); The levels of IL-2, IL-6, and TFN-α in the observation group after treatment were lower than those before treatment and in the control group (P<0.05); There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 The use of Wushe Rongpi decoction in the treatment of MHD patients with skin itching has a significant therapeutic effect, can improve the patient's immune function, reduce serum IL-2, IL-6, TFN-α levels, and traditional Chinese medicine symptom scores, and has minimal adverse reactions.
杨雪梅, 余光青, 李文丽, 闫建锋. 乌蛇荣皮汤治疗维持性血液透析伴皮肤瘙痒患者的临床疗效及对患者免疫功能的影响[J]. 医学临床研究, 2024, 41(1): 109-112.
YANG Xuemei, YU Guangqing, LI Wenli, et al. Clinical Efficacy and Impact on Immune Function of Wushe Rongpi Decoction in the Treatment of Maintenance Hemodialysis Patients with Skin Itching. JOURNAL OF CLINICAL RESEARCH, 2024, 41(1): 109-112.
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2024, Vol. 41 
