Abstract：【Objective】To investigate the clinical efficacy and application of Xiaoyaosan Jiawei Granule in combination with external application of traditional Chinese medicine (TCM) (named Tazi) in the treatment of Hashimoto's thyroiditis. 【Methods】A total of 66 patients with Hashimoto's thyroiditis treated in Yulin City Traditional Chinese Medicine Hospital and Xi'an Beilin District Traditional Chinese Medicine Hospital from January 2020 to December 2021 were selected as the study subjects. They were randomly allocated into two groups: a control group and a treatment group, each comprising 33 patients. Patients in the treatment group received oral administration of Xiaoyaosan Jiawei (flavor added granules) and external application of TCM (Tazi), while patients in the control group were treated with oral selenium yeast. The clinical efficacy, thyroid function indicators, thyroid-related antibody levels, and TCM symptom and sign scores of the two groups were compared. 【Results】The overall effectiveness rate of the treatment group was significantly greater than the control group (P<0.05). Thyroid-stimulating hormone (TSH) level decreased in both control and treatment groups after treatment; and the TSH level in the tratmentn group was significantly lower than that in the control group (P<0.05). The levels of free triiodothyronine (FT3) and free thyroxine (FT4) increased significantly in both groups after treatment, while levels of FT3 and FT4 in the treatment group were significantly higher those in the control group(P<0.05). Serum thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) levels significantly decreased after treatment in both groups (P<0.05), with significantly lower levels in the treatment group compared to the control group (P<0.05). Post-treatment, scores of TCM symptoms and signs such as fatigue, shortness of breath, weakness in the waist and knees, dry mouth and throat, weight loss, palpitations, insomnia, irritability, spontaneous and night sweats, and loose stools were significantly higher in the control group than in the treatment group (P<0.05). 【Conclusion】The combined treatment method of oral administration of Xiaoyaosan Jiawei and external application of TCM (Tazi) significantly improved thyroid function and reduced the levels of autoantibodies in patients, and effectively alleviated clinical symptoms and signs, achieving the purpose of treating both the root and the symptoms.
王府存, 李茂林. 逍遥散加味颗粒联合中药塌渍外敷治疗桥本甲状腺炎患者的临床效果[J]. 医学临床研究, 2024, 41(2): 188-191.
WANG Fucun, LI Maolin. Clinical Effect of Xiaoyaosan Jiawei Granule Combined Chinese Medicine for External Use in the Treatment of Hashimoto Thyroiditis. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 188-191.
2024, Vol. 41 
