维得利珠单抗联合美沙拉嗪治疗炎症性肠病的临床疗效及安全性分析

doi:10.3969/j.issn.1671-7171.2024.01.026

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摘要【目的】探讨维得利珠单抗联合美沙拉嗪治疗炎症性肠病的临床疗效及安全性。【方法】选取2021年1月至2022年12月南阳医学高等专科学校第一附属医院收治的84例炎症性肠病患者,采用随机数字表法将其分为常规组和联合组,每组42例。常规组给予美沙拉嗪,联合组在常规组的基础上给予维得利珠单抗,两组均在第8周观察治疗效果。比较两组临床疗效、外周血炎症因子[血清白细胞介素-4(IL-4)、白细胞介素-17(IL-17)]、炎症性肠病生活质量问卷(IBDQ)评分情况,记录治疗期间药物不良反应发生情况。【结果】联合组总有效率为95.24%(40/42),高于常规组的78.57%(33/42),差异有统计学意义(χ²=5.126,P<0.05)。治疗后,两组患者血清IL-4、IL-17水平均低于治疗前,且联合组低于常规组,差异有统计学意义(P<0.05)。常规组、联合组治疗前IBDQ评分分别为(115.89±12.93)分、(113.27±11.85)分,两组治疗后分别为(182.34±15.48)分、(198.15±7.26)分。治疗后,两组患者IBDQ评分高于治疗前,且联合组高于常规组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(χ²=0.156,P=0.693)。【结论】维得利珠单抗联合美沙拉嗪治疗炎症性肠病可提高治疗效果,抑制炎症因子合成,改善患者生活质量,安全性良好。

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	马真真
	朱冰洋
	方金涛

关键词 ：炎性肠疾病/药物疗法, 抗体,单克隆/治疗应用, 氨水杨酸/治疗应用, 治疗结果

Abstract：【Objective】 To explore the clinical efficacy and safety of combination therapy with Vedolizumab and Mesalazine in the treatment of inflammatory bowel disease.【Methods】 A total of 84 patients with inflammatory bowel disease admitted to the First Affiliated Hospital of Nanyang Medical College from January 2021 to December 2022 were selected. They were randomly divided into a conventional group and a combination group using a random number table method, with 42 patients in each group. The conventional group was given Mesalazine, while the combination group was given Vedrizumab in addition to the conventional group. The treatment effect was observed in both groups at week 8. We compared the clinical efficacy, peripheral blood inflammatory factors [serum interleukin-4 (IL-4), interleukin-17 (IL-17)], and inflammatory bowel disease quality of life questionnaire (IBDQ) scores between two groups, and recorded the occurrence of adverse drug reactions during treatment.【Results】 The total effective rate of the combined group was 95.24%(40/42), which was higher than the conventional group's 78.57%(33/42), and the difference was statistically significant (χ²=5.126, P<0.05). After treatment, the serum levels of IL-4 and IL-17 in both groups of patients were lower than before treatment, and the combined group was lower than the conventional group, with statistical significance (P<0.05). The IBDQ scores of the conventional group and the combination group before treatment were (115.89±12.93) points and (113.27±11.85) points, respectively. After treatment, the scores of the two groups were (182.34±15.48) points and (198.15±7.26) points, respectively. After treatment, the IBDQ scores of the two groups of patients were higher than before treatment, and the combination group was higher than the conventional group, with a statistically significant difference (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (χ²=0.156, P=0.693). 【Conclusion】 The combination of Vedolizumab and Mesalazine in the treatment of inflammatory bowel disease can enhance the therapeutic effect, inhibit the synthesis of inflammatory factors, improve the quality of life of patients, and have good safety.

Key words： Inflammatory Bowel Diseases/DT Antibodies, Monoclonal/TU Mesalamine/TU Treatment Outcome

收稿日期: 2023-03-14

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R574

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引用本文:

马真真, 朱冰洋, 方金涛. 维得利珠单抗联合美沙拉嗪治疗炎症性肠病的临床疗效及安全性分析[J]. 医学临床研究, 2024, 41(1): 95-98.
MA Zhenzhen, ZHU Bingyang, FANG Jintao. Clinical Efficacy and Safety Analysis of the Combination of Vedolizumab and Mesalazine in the Treatment of Inflammatory Bowel Disease. JOURNAL OF CLINICAL RESEARCH, 2024, 41(1): 95-98.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.01.026 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I1/95