酮咯酸氨丁三醇联合右美托咪定用于剖宫产术中的超前镇痛效果

doi:10.3969/j.issn.1671-7171.2023.05.015

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1165 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要【目的】探讨酮咯酸氨丁三醇(KT)联合右美托咪定(Dex)用于剖宫产术中的超前镇痛效果。【方法】在本院行剖宫产术的180例产妇,按照入院先后顺序将其分成两组,每组90例,对照组予以Dex加等容量生理盐水超前镇痛,观察组予以KT联合Dex超前镇痛。比较两组术后寒战发生情况、术后疼痛情况、围术期应激激素水平、不良反应发生情况和新生儿Apgar评分。【结果】观察组术后寒战总发生率低于对照组(P<0.05)。观察组术后6 h、术后12 h、术后24 h视觉模拟评分法(VAS)评分均低于对照组(P<0.05)。术后2 h(T₁)时两组肾素(Rn)、皮质醇(Cor)、促肾上腺皮质激素(ACTH)均高于硬膜外穿刺前(T₀)(P<0.05),且T₁时观察组Rn、Cor、ACTH均低于对照组(P<0.05)。手术次日上午8点(T₂)时两组Rn、Cor、ACTH均高于T₀时(P<0.05),对照组Rn、Cor、ACTH均高于T₁时(P<0.05),且T₂时观察组Rn、Cor、ACTH均低于对照组(P<0.05)。观察组恶心、呕吐发生率低于对照组(P<0.05)。两组新生儿1 min和5 min Apgar评分比较,差异均无统计学意义(P>0.05)。【结论】KT联合Dex超前镇痛用于剖宫产术,能预防术后寒战发生,增强术后镇痛效果,抑制围术期应激反应,减少不良反应,且不影响新生儿Apgar评分。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	高怀新
	蒋留琴

关键词 ：酮咯酸氨丁三醇/药理学, 右美托咪定/药理学, 剖宫产术, 镇痛

Abstract：【Objective】To investigate the effect of ketorolac tromethamine (KT) combined with dexmedetomidine (Dex) on preemptive analgesia in patients undergoing cesarean section. 【Methods】A total of 180 patients with cesarean section in our hospital were divided into two groups according to the order of admission. The 90 cases in the control group were given Dex plus equal volume normal saline for preemptive analgesia,and 90 cases in the observation group were given KT combined with Dex for preemptive analgesia. The incidence of postoperative shivering,postoperative pain,perioperative stress hormone levels,adverse reactions,and neonatal Apgar score were compared between the two groups. 【Results】The total incidence of postoperative shivering in the observation group was lower than that in the control group (P<0.05). The visual analogue scale (VAS) scores of the observation group at 6 h,12 h and 24 h after operation were lower than those of the control group at the same time points (P<0.05). The levels of renin (Rn),cortisol (Cor) and adrenocorticotropic hormone (ACTH) in the two groups at 2h after operation (T₁) were higher than those before epidural puncture (T₀) (P<0.05),and the levels of Rn,Cor and ACTH in the observation group at T₁ were lower than those in the control group at T₁ (P<0.05). After surgery,Rn,Cor,and ACTH levels of the two groups at T₂ (8:00 am the next day post-operation) were higher than those at T₀ (P<0.05). The levels of Rn,Cor and ACTH in the control group were higher than those at T₁ (P<0.05),while the levels of Rn,Cor and ACTH in the observation group at T₂ were lower than those in the control group at T₂ (P<0.05). The incidence of nausea and vomiting in the observation group was lower than that in the control group (P<0.05). There was no significant difference in newborn Apgar score at 1 min and 5 min between the two groups (P>0.05). 【Conclusion】KT combined with Dex for preemptive analgesia in cesarean section can prevent postoperative shivering,enhance postoperative analgesic effect,inhibit perioperative stress reaction and reduce adverse reactions,while it does not affect the neonatal Apgar score.

Key words： Ketorolac Tromethamine/PD Dexmedetomidine/PD Cesarean Section Analgesia

收稿日期: 2022-05-20

中图分类号:

R719.8

通讯作者: *E-mail:1229281592@qq.com

引用本文:

高怀新, 蒋留琴. 酮咯酸氨丁三醇联合右美托咪定用于剖宫产术中的超前镇痛效果[J]. 医学临床研究, 2023, 40(5): 692-694.
GAO Huai-xin, JIANG Liu-qin. Effect of Ketorolac Tromethamine Combined with Dexmedetomidine on Preemptive Analgesia in Patients Undergoing Cesarean Section. JOURNAL OF CLINICAL RESEARCH, 2023, 40(5): 692-694.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.05.015 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I5/692